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Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines.
TLDR
It is reported herein that (-)-epigallocatechin-3-gallate (EGCG), the major polyphenol from green tea, can inhibit DNMT activity and reactivate methylation-silenced genes in cancer cells and the potential use of EGCG for the prevention or reversal of related gene-silencing in the prevention of carcinogenesis is suggested. Expand
Pharmacokinetics of tea catechins after ingestion of green tea and (-)-epigallocatechin-3-gallate by humans: formation of different metabolites and individual variability.
TLDR
The pharmacokinetic parameters of EGCG, EGC, and EC were analyzed after administration of a single oral dose of green tea or decaffeinated green tea to eight subjects and may be useful for designing the dose and dose frequency in intervention studies with tea and for development of biomarkers of tea consumption. Expand
Increased Protein Stability as a Mechanism That Enhances Nrf2-mediated Transcriptional Activation of the Antioxidant Response Element
TLDR
It is found that the levels of Nrf2 were increased in cells treated with tert-butylhydroquinone or β-naphthoflavone by a post-transcriptional mechanism, suggesting that NRF2 is degraded by the ubiquitin-dependent pathway and that phosphorylation of N RF leads to an increase in its stability and subsequent transactivation activity. Expand
Reversal of Hypermethylation and Reactivation of p16INK4a, RARβ, and MGMT Genes by Genistein and Other Isoflavones from Soy
TLDR
Results indicate that genistein and related soy isoflavones reactivate methylation-silenced genes, partially through a direct inhibition of DNA methyltransferase, which may contribute to the chemopreventive activity of dietary is oflavones. Expand
Stability, cellular uptake, biotransformation, and efflux of tea polyphenol (-)-epigallocatechin-3-gallate in HT-29 human colon adenocarcinoma cells.
TLDR
The results suggest that EGCG is metabolized in the cell and that the metabolites are pumped out by MRPs, and suggests the need for careful interpretation of related results on the biological activities of E GCG. Expand
Mechanism of action of (-)-epigallocatechin-3-gallate: auto-oxidation-dependent inactivation of epidermal growth factor receptor and direct effects on growth inhibition in human esophageal cancer
TLDR
The results suggest that in cell culture conditions, the auto-oxidation of EGCG leads to EGFR inactivation, but the inhibition of cell growth is due to other mechanisms. Expand
The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress.
TLDR
The mechanisms controlling this activation process as reported in recent studies will be examined and discussed, with particular emphasis on those affecting Nrf2 stability at the molecular level. Expand
Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase.
TLDR
Curcumin affects arachidonic acid metabolism by blocking the phosphorylation of cPLA(2), decreasing the expression of COX-2 and inhibiting the catalytic activities of 5-LOX, which may contribute to the anti-inflammatory and anticarcinogenic actions of curcumin and its analogs. Expand
Nrf2 Controls Constitutive and Inducible Expression of ARE-driven Genes through a Dynamic Pathway Involving Nucleocytoplasmic Shuttling by Keap1*
TLDR
It is suggested that the stabilization of Nrf2 in cells under stress represents the central regulatory response mediated by mechanisms that interfere with its interaction with Keap1, leading to the induction of antioxidant enzymes important to maintain cellular redox homeostasis. Expand
Pro-oxidative activities and dose-response relationship of (-)-epigallocatechin-3-gallate in the inhibition of lung cancer cell growth: a comparative study in vivo and in vitro.
TLDR
Although E GCG is generally considered to be an antioxidant, the present study demonstrates the pro-oxidative activities of EGCG in vivo and in vitro in the described experimental system. Expand
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