• Publications
  • Influence
Diamidine Compounds for Selective Inhibition of Protein Arginine Methyltransferase 1
Protein arginine methylation is a posttranslational modification critical for a variety of biological processes. Misregulation of protein arginine methyltransferases (PRMTs) has been linked to manyExpand
  • 58
  • 6
Structural mechanism of ATP-independent transcription initiation by RNA polymerase I
Transcription initiation by RNA Polymerase I (Pol I) depends on the Core Factor (CF) complex to recognize the upstream promoter and assemble into a Pre-Initiation Complex (PIC). Here, we solve aExpand
  • 39
  • 3
Structurally distinct ubiquitin- and sumo-modified PCNA: implications for their distinct roles in the DNA damage response.
Proliferating cell nuclear antigen (PCNA) is a pivotal replication protein, which also controls cellular responses to DNA damage. Posttranslational modification of PCNA by SUMO and ubiquitin modulateExpand
  • 30
  • 2
Understanding the specificity of a docking interaction between JNK1 and the scaffolding protein JIP1.
The up-regulation of JNK activity is associated with a number of disease states. The JNK-JIP1 interaction represents an attractive target for the inhibition of JNK-mediated signaling. In this study,Expand
  • 29
  • 1
Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability
Processivity clamps such as proliferating cell nuclear antigen (PCNA) and the checkpoint sliding clamp Rad9/Rad1/Hus1 (9-1-1) act as versatile scaffolds in the coordinated recruitment of proteinsExpand
  • 35
  • 1
  • PDF
A Model of a MAPK•Substrate Complex in an Active Conformation: A Computational and Experimental Approach
The mechanisms by which MAP kinases recognize and phosphorylate substrates are not completely understood. Efforts to understand the mechanisms have been compromised by the lack of MAPK-substrateExpand
  • 20
  • 1
Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1
Human flap endonuclease 1 (FEN1) and related structure-specific 5’nucleases precisely identify and incise aberrant DNA structures during replication, repair and recombination to avoid genomicExpand
  • 22
  • 1
Natural Product Micheliolide (MCL) Irreversibly Activates Pyruvate Kinase M2 and Suppresses Leukemia
  • J. Li, S. Li, +20 authors Yue Chen
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 11 April 2018
Metabolic reprogramming of cancer cells is essential for tumorigenesis in which pyruvate kinase M2 (PKM2), the low activity isoform of pyruvate kinase, plays a critical role. Herein, we describe theExpand
  • 23
  • 1
Reversible Covalent Inhibition of eEF‐2K by Carbonitriles
eEF‐2K is a potential target for treating cancer. However, potent specific inhibitors for this enzyme are lacking. Previously, we identifiedExpand
  • 13
  • 1
  • PDF
Secondary Interaction Interfaces with PCNA Control Conformational Switching of DNA Polymerase PolB from Polymerization to Editing.
Replicative DNA polymerases (Pols) frequently possess two distinct DNA processing activities: DNA synthesis (polymerization) and proofreading (3'-5' exonuclease activity). The polymerase andExpand
  • 18
  • 1