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The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response.
  • J. Zhou, C. Liu, +4 authors R. Kaufman
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 26 September 2006
The unfolded protein response (UPR) is an evolutionarily conserved mechanism by which all eukaryotic cells adapt to the accumulation of unfolded proteins in the endoplasmic reticulum (ER).Expand
Ligand-independent Dimerization Activates the Stress Response Kinases IRE1 and PERK in the Lumen of the Endoplasmic Reticulum*
TLDR
It is proposed that ligand-independent activation of IRE1 and PERK permits homodimerization upon accumulation of unfolded proteins in the lumen of the ER. Expand
Spectral characteristics and interconversions of the reduced oxidized, and oxygenated forms of purified cytochrome o.
TLDR
The spectrum of the "oxygenated" form of the reduced cytochrome, which has absorption maxima at 576, 543, and 414 nm, is elicited in aerobic solution by enzymatic reduction with NADH, and when formed in this way the oxygenated form is very stable. Expand
Reduced nicotinamide adenine dinucleotide cytochrome o reductase associated with cytochrome o purified from Vitreoscilla. Evidence for an intermediate oxygenated form of cytochrome o.
Abstract Cytochrome o, purified from Vitreoscilla sp., Murray strain 389, has a carbon monoxide difference spectrum with absorption maxima at 569, 535, and 419 nm. This spectrum resembles closely theExpand
A point mutation in the cysteine-rich domain of glycoprotein (GP) IIIa results in the expression of a GPIIb-IIIa (alphaIIbbeta3) integrin receptor locked in a high-affinity state and a Glanzmann
TLDR
Data demonstrate that a gain-of-function mutation can still be associated with a thrombasthenic phenotype even though platelets show spontaneous fibrinogen binding. Expand
The binding of thrombin by fibrin.
Human plasma prekallikrein: a rapid high-yield method for purification.
TLDR
The final step of purification was affinity chromatography on agarose coupled to antiserum to human IgG to remove contaminating IgG and a single peak of protein emerged coincident with prekallikrein antigen representing an overall yield of 39% of the starting material. Expand
Fibrin polymerization and release of fibrinopeptide B by thrombin.
TLDR
It is suggested that a number of other reactions in the hemostatic system including fibrinolysis which appear to be sequential are also simultaneous and that it is the more rapid formation of fibrin I which results in the appearance of a sequential reaction. Expand
Potentiation of the function of Hageman factor fragments by high molecular weight kininogen.
TLDR
The results suggest that one of the functions of HMW kininogen is to augment the catalytic action of HFf, and that the hydrolysis of acetylglycyl-lysine methyl ester by HFf was increased by HMW Kininogen. Expand
Characterization of fibrinogen New York 1. A dysfunctional fibrinogen with a deletion of B beta(9-72) corresponding exactly to exon 2 of the gene.
TLDR
Amino acid sequence analyses demonstrated that the abnormal B beta-chain is the result of a deletion in the sequence from residues 9 to 72, which corresponds exactly to exon 2 of the gene. Expand
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