Tetrodotoxin, saxitoxin and their significance in the study of excitation phenomena.
- C. Y. Kao
- MedicinePharmacological Reviews
Sodium and Calcium Inward Currents in Freshly Dissociated Smooth Myocytes of Rat Uterus
Estrogen-enhanced genomic influences may account for the emergence of Ina, and increased densities of INa and ICa as pregnancy progresses, and other influences may regulate varied channel expression at different stages of pregnancy.
Potassium Currents in Freshly Dissociated Uterine Myocytes from Nonpregnant and Late-Pregnant Rats
- S. Wang, M. Yoshino, J. Sui, M. Wakui, P. Kao, C. Y. Kao
- BiologyThe Journal of general physiology
- 1 December 1998
In late-pregnancy, myometrial excitability is increased by changes in K+ currents that include a suppression of the ITO, a redistribution of IK expression from large-conductance Ca2+-activated channels to smaller- conductance delayed rectifier channels, a lowered Ca2+.
Structure‐Activity Relations of Tetrodotoxin, Saxitoxin, and Analogues a, b
- C. Y. Kao
- ChemistryAnnals of the New York Academy of Sciences
- 1 December 1986
Pharmacological studies on tarichatoxin, a potent neurotoxin.
Almost all the systemic effects produced by tarichatoxin can be ascribed to a block of the preganglionic cholinergic and the somatic motor nerves.
Permeation, selectivity, and blockade of the Ca2+-activated potassium channel of the guinea pig taenia coli myocyte
The findings suggest that the 147-pS Ca2+-activated K+ channel in the taenia myocytes, which functions physiologically like the delayed rectifier, is the single- channel basis of the repolarizing current in an action potential.
Graded and decremental response in heart muscle fibers.
The results obtained indicate that the transition from graded to all-or-none response does not depend solely on the restoration of membrane potential.
Actions of saxitoxin on peripheral neuromuscular systems.
Refractoriness in cardiac muscle.
- B. Hoffman, C. Y. Kao, E. Suckling
- Biology, MedicineThe American journal of physiology
- 1 September 1957
A preparation consisting of a papillary muscle and attached bundle of Purkinje fibers has been employed to study refractoriness of single cardiac fibers of the dog heart. Transmembrane stimulation ...