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Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development.
Human contains 49 ATP-binding cassette (ABC) transporter genes and the multidrug resistance associated proteins (MRP1/ABCC1, MRP2/ABCC2, MRP3/ABCC3, MRP4/ABCC4, MRP5/ABCC5, MRP6/ABCC6, MRP7/ABCC10,Expand
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Clinically Important Drug Interactions Potentially Involving Mechanism-based Inhibition of Cytochrome P450 3A4 and the Role of Therapeutic Drug Monitoring
Cytochrome P450 (CYP) 3A4 is the most abundant enzyme of CYPs in the liver and gut that metabolizes approximately 50% currently available drugs. A number of important drugs have been identified asExpand
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Identification of drugs that interact with herbs in drug development.
To date, several clinically important drugs have been identified that interact with commonly used herbs. These drugs include (among others) warfarin, midazolam, digoxin, amitriptyline, indinavir,Expand
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Effect of acupuncture in the treatment of seasonal allergic rhinitis: a randomized controlled clinical trial.
The clinical efficacy and safety of acupuncture in the treatment of Seasonal Allergic Rhinitis (SAR) was evaluated by employing a two-phase crossover single-blind clinical trial. Thirty subjects wereExpand
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A pharmacogenetic study of pregnane X receptor (NR1I2) in Han Chinese.
The pregnane X receptor (PXR/NR1I2) gene is a critical transcriptional regulator of a number of important drug metabolizing enzymes and transporters. This study was undertaken to determine theExpand
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A Pharmacological Review of Bioactive Constituents of Paeonia lactiflora Pallas and Paeonia veitchii Lynch
The roots of two peony species, Paeonia lactiflora Pallas and Paeonia veitchii Lynch are routinely referred to as either chishao (赤芍) or baishao (白芍). This paper reviews the botanical origins andExpand
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Modalities of Chinese Medicine
Chinese medicine uses a number of modalities or therapies for both prevention and treatment of disease. There are two main categories of treatment modalities: herbal and manual treatment. ManyExpand
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Clinical pharmacogenetics and potential application in personalized medicine.
The current 'fixed-dosage strategy' approach to medicine, means there is much inter-individual variation in drug response. Pharmacogenetics is the study of how inter-individual variations in the DNAExpand
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Clinical drugs that interact with St. John's wort and implication in drug development.
St. John's wort (Hypericum perforatum, SJW) is one of the most commonly used herbal antidepressants for the treatment of minor to moderate depression. A major safety concern about SJW is its abilityExpand
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Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: an update.
In recent years, there has been a globally increasing application of herbal medicines and dietary supplements to treat various chronic diseases and to promote health. However, there are increasingExpand
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