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Association of Cytotoxic T Lymphocyte-associated antigen-4 gene haplotype with the susceptibility to gastric cancer
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) was widely accepted as a pivotal molecule in downregulating T-cell mediated immune responses. In this study we investigated the polymorphismsExpand
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Association of genetic polymorphisms in MDM2, PTEN and P53 with risk of esophageal squamous cell carcinoma
Genetic variations in MDM2, PTEN and P53 might be involved in cancer susceptibility. To assess the contribution of polymorphisms in these three genes to the risk of esophageal squamous cell carcinomaExpand
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Association of interferon-gamma gene haplotype in the Chinese population with hepatitis B virus infection
In general, cytokines encoded by different genes of human genome might strongly influence host cell-mediated immune responses, which play an important role in the clearance of virus by the infectedExpand
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Genetic variations and haplotypes in TIM-3 gene and the risk of gastric cancer
PurposeT cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) could weaken the Th1-mediated anti-tumor responses and accelerate the tumor cell proliferation by inhabiting the productionExpand
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Effects of selected genetic polymorphisms in xeroderma pigmentosum complementary group D on gastric cancer
DNA repair capacity (DRC) can be altered based on sequence variations in DNA repair genes, which may result in cancer susceptibility. The current study was to evaluate the association between geneticExpand
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Genetic Polymorphisms of LMP/TAP Gene and Hepatitis B Virus Infection Risk in the Chinese Population
Despite the availability of effective vaccines, hepatitis B virus (HBV) infection is still commonly seen worldwide. Several reports show that the human major histocompatability complex (MHC) systemsExpand
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Association of the −183 polymorphism in the IFN‐γ gene promoter with hepatitis B virus infection in the Chinese population
Interferon‐γ (IFN‐γ) is a pleiotropic cytokine that plays an important role in regulating cellular immune responses. Regulation of IFN‐γ expression is considered to be strictly controlled at theExpand
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Functional polymorphisms of caveolin-1 variants as potential biomarkers of esophageal squamous cell carcinoma
Abstract Objective: To investigate the association of caveolin-1 (CAV1) genetic variants (C239A (rs1997623), G14713A (rs3807987), G21985A (rs12672038), T29107A (rs7804372)) with esophageal squamousExpand
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Association analysis of hepatitis virus B infection with haplotypes of the TBX21 gene promoter region in the Chinese population
  • B. Cao, H. Yang, +5 authors C. Xu
  • Biology, Medicine
  • Clinical chemistry and laboratory medicine
  • 2007
Abstract Background: The T-box21 (TBX21) gene encodes the transcription factor T-bet (T-box expressed in T-cells), which influences naive T-lymphocyte development and has been implicated in theExpand
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Association of the Genetic Polymorphisms in XRCC6 and XRCC5 with the Risk of ESCC in a High-incidence Region of North China
Background The XRCC6 and XRCC5 genes are part of the nonhomologous end-joining (NHEJ) pathway, which is the main mechanism repairing DNA double-strand breaks (DSBs) in human cells. Genetic variationsExpand
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