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Metalloid resistance mechanisms in prokaryotes.
This review focuses on the biochemistry of the proteins of the ars operon of R-factor R773, which is novel in several respects and provides a high affinity digital switch to turn the regulated protein on with rapidity. Expand
The Chromosomal arsR Gene of Escherichia coli Encodes a trans-acting Metalloregulatory Protein (*)
It was shown that ArsR is a trans-acting repressor that regulates expression of the chromosomally encoded ars operon, and the R773 repressor can cross-regulate expression from the chromosomal operon. Expand
In vivo studies of cadmium-induced apoptosis in testicular tissue of the rat and its modulation by a chelating agent.
Characteristic DNA migration patterns (laddering) provide evidence of apoptosis (programmed cell death) in testicular tissue of rats administered CdCl2 at a level of 0.03 mmol/kg 48 h previously. Expand
Effect of monoisoamyl meso-2,3-dimercaptosuccinate on the pathology of acute cadmium intoxication.
The antagonistic effects of Mi-ADMS treatment on cadmium intoxication in the kidneys and the testes of rats is very similar to that found for effective dithiocarbamate antagonists. Expand
Cadmium-induced apoptosis in the urogenital organs of the male rat and its suppression by chelation.
Cadmium-induced apoptosis is shown to occur, in vivo, in several organs of the male Wistar rat urogenital system, 48 h after cadmium administration i.p. at a dose of 0.03 mmol/kg. Characteristic DNAExpand
Photosensitization of the Sunscreen Octyl p-Dimethylaminobenzoate by UVA in Human Melanocytes but not in Keratinocytes¶
The results indicate that sunscreens may increase cell mobility and the combination of o-PABA with solar UV may selectively damage melanocytes in the skin. Expand
Dimerization Is Essential for DNA Binding and Repression by the ArsR Metalloregulatory Protein of Escherichia coli*
  • C. Xu, B. Rosen
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 20 June 1997
The results suggest that a core sequence of about 80 residues has all of the information necessary for dimerization, repression, and metal recognition in arsenic resistance operons. Expand
Properties of microtubules assembled from mammalian tubulin synthesized in Escherichia coli.
Results demonstrate that the naturally occurring mixtures of isoforms are not strictly required for the formation of microtubules, and open a route to other studies, both biomedical and structural, of fully defined tubulin in vitro. Expand
Analysis of products formed during bleomycin-mediated DNA degradation.
By the use of DNA, copolymers of defined nucleotide composition, and a synthetic dodecanucleotide having putative bleomycin cleavage sites in proximity to the 5'- and 3'-termini, the products formedExpand
Chemistry of the alkali-labile lesion formed from iron(II) bleomycin and d(CGCTTTAAAGCG).
By use of the self-complementary dodecanucleotide d(CGCTTTAAAGCG) having a site modified by Fe-bleomycin three nucleotides from the 5'-end, it has been possible to characterize the alkali-labile product as a C-4' hydroxyapurinic acid. Expand