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DNA vaccines: a key for inducing long-term cellular immunity.
Over the past few years, major advances in several areas of immunology have provided a foundation for the rational design of vaccines against diseases requiring cellular immunity. Among theseExpand
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Detection of methicillin-resistant staphylococci by using the polymerase chain reaction.
A polymerase chain reaction (PCR)-based test was developed for the detection of mecA in staphylococci. To facilitate this process, a rapid cell lysis procedure was established for the release of DNAExpand
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A54145 a new lipopeptide antibiotic complex: microbiological evaluation.
A54145 complex is made up of eight factors; A, A1, B, B1, C, D, E, and F which were active in vitro (MIC 0.25 approximately greater than 32 micrograms/ml) against Gram-positive aerobic organisms. TheExpand
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Characterization of vancomycin resistance in Enterococcus faecium and Enterococcus faecalis.
Vancomycin resistance in Enterococcus faecium 180, a clinical isolate from England, was studied. Resistance to vancomycin was transferable by conjugation to other enterococci. Expression ofExpand
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Evaluation of the anti-influenza virus activities of 1,3,4-thiadiazol-2-ylcyanamide (LY217896) and its sodium salt.
1,3,4-Thiadiazol-2-ylcyanamide (LY217896) and its sodium salt were shown to be effective against influenza A and B viruses in vitro and in the mouse model. In nondividing confluent MDCK cells, theExpand
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Synthesis and antimicrobial evaluation of dirithromycin (AS-E 136; LY237216), a new macrolide antibiotic derived from erythromycin.
Dirithromycin is a 9-N-11-O-oxazine derivative which is formed by condensation of 9(S)-erythromycylamine with 2-(2-methoxyethoxy)acetaldehyde. Dirithromycin is hydrolyzed, either under acidicExpand
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Biological characterization of a new radioactive labeling reagent for bacterial penicillin-binding proteins.
Radiolabeled penicillin G is widely used as the imaging agent in penicillin-binding protein (PBP) assays. The disadvantages of most forms of labeled penicillin G are instability on storage and theExpand
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Kinetic studies of the inhibitory effects of propeptides subtilisin BPN' and Carlsberg to bacterial serine proteases.
The propeptides of bacterial subtilisin BPN' and Carlsberg were synthesized to investigate their inhibitory function on the enzymes. Kinetically, pro-BPN' inhibits the proteolytic activities ofExpand
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Protein Synthesis in Isolated Mitochondria of Rice (Oryza sativa L.) Seedlings.
For studies of in organello mitochondrial protein synthesis in rice, Oryza sativa L., conventional surface-sterilization procedures were demonstrated to be ineffective. Because of the over-whelminglyExpand
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An Implantable, Synchronous Pacemaker for the Long‐Term Correction of Complete Heart Block
An implantable, synchronous cardiac pacemaker for long-term correction of complete heart block has been developed. It has been successfully used in dogs for periods up to eight months. TheExpand
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