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The effect of osteoimmunomodulation on the osteogenic effects of cobalt incorporated β-tricalcium phosphate.
TLDR
It is demonstrated that the inclusion of immune cells (macrophages) in the in-vitro assessment matched the in vivo tissue response, and that this method provides a more accurate indication of the essential role of immune Cells when assessing materials-stimulated osteogenesis in Vitro.
Preparation and characteristics of a calcium magnesium silicate (bredigite) bioactive ceramic.
TLDR
The results showed that bredigite ceramics could induce HAp formation in SBF and the products from bredIGite dissolution significantly promoted cell growth at a certain concentration range.
Advances in synthesis of calcium phosphate crystals with controlled size and shape.
TLDR
This review summarizes the current state of the art for the synthesis of CaP crystals with controlled sizes from the nano- to the macroscale, and the diverse shapes including the zero-dimensional shapes of particles and spheres, the one- dimensional shapes of rods, fibers, wires and whiskers, the two-dimensionalshape of sheets, disks, plates, belts, ribbons and flakes and the three-dimensional shape of porous, hollow, and biomimetic structures similar to biological bone and tooth.
Hypoxia-mimicking mesoporous bioactive glass scaffolds with controllable cobalt ion release for bone tissue engineering.
TLDR
The results showed that low amounts of Co (<5%) incorporated into MBG scaffolds had no significant cytotoxicity and that their incorporation significantly enhanced VEGF protein secretion, HIF-1α expression, and bone-related gene expression in BMSCs, and also that the Co-MBG scaffolding support BMSC attachment and proliferation.
Osteogenic differentiation of bone marrow MSCs by β-tricalcium phosphate stimulating macrophages via BMP2 signalling pathway.
TLDR
Interestingly, when macrophage-conditioned β-TCP extracts were applied to bone marrow mesenchymal stem cells (BMSCs), the osteogenic differentiation of BMSCs was significantly enhanced, indicating the important role of macrophages in biomaterial-induced osteogenesis.
Copper-containing mesoporous bioactive glass scaffolds with multifunctional properties of angiogenesis capacity, osteostimulation and antibacterial activity.
TLDR
It is demonstrated that it is possible to develop multifunctional scaffolds by combining enhanced angiogenesis potential, osteostimulation, and antibacterial properties for the treatment of large bone defects.
The effect of strontium incorporation into CaSiO3 ceramics on their physical and biological properties.
TLDR
The results indicate that Sr-CaSiO3 ceramics improved the physical and biological properties of the pure CaSiO2 ceramic and did not alter the mechanism and ability of apatite formation in SBF.
The effects of pore architecture in silk fibroin scaffolds on the growth and differentiation of mesenchymal stem cells expressing BMP7.
TLDR
It is shown that an optimized pore architecture of silk fibroin scaffolds can modulate the bioactivity of BMP7-transfected BMSC in bone formation, with better cell proliferation and ECM production.
Three-dimensional printing of hierarchical and tough mesoporous bioactive glass scaffolds with a controllable pore architecture, excellent mechanical strength and mineralization ability.
TLDR
3-D printed Mesoporous bioactive glass scaffolds obtained possess a high mechanical strength about 200 times that of traditional polyurethane foam templated MBG scaffolds, and have a highly controllable pore architecture, excellent apatite mineralization ability and sustained drug delivery properties.
The effect of silicate ions on proliferation, osteogenic differentiation and cell signalling pathways (WNT and SHH) of bone marrow stromal cells.
TLDR
The results suggest that Si ions by themselves play an important role in regulating the proliferation and osteogenic differentiation of BMSCs, with the involvement of WNT and SHH signalling pathways.
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