A microwell cytotoxicity assay using Artemia salina (brine shrimp).
- P. Solis, C. Wright, M. Anderson, M. Gupta, J. Phillipson
- BiologyPlanta Medica
- 1 June 1993
A new microplate assay for cytotoxicity testing using A. salina has been developed and shown to give results comparable to a previously published test-tube method, except for two which require metabolic activation in man.
Use of microdilution to assess in vitro antiamoebic activities of Brucea javanica fruits, Simarouba amara stem, and a number of quassinoids
- C. Wright, M. J. O'neill, J. Phillipson, D. Warhurst
- BiologyAntimicrobial Agents and Chemotherapy
- 1 November 1988
A microdilution technique for the assessment of in vitro activity against Entamoeba histolytica was devised and validated with metronidazole and will be useful in the search for novel antiamoebic drugs.
Can ethnopharmacology contribute to the development of antimalarial agents?
- J. Phillipson, C. Wright
- MedicineJournal of Ethnopharmacology
- 1 April 1991
Natural products and the development of selective antiprotozoal drugs
- C. Wright, J. Phillipson
- Biology, Chemistry
- 1 August 1990
The potential of natural plant products as a source of antiprotozoal drugs is discussed with respect to biochemical differences between protozoa and hosts with emphasis onalkaloids, terpenes, quinones and miscellaneous compounds.
Synthesis and evaluation of cryptolepine analogues for their potential as new antimalarial agents.
- C. Wright, J. Addae-Kyereme, P. Pollet
- Biology, ChemistryJournal of Medicinal Chemistry
- 18 August 2001
The indoloquinoline alkaloid cryptolepine 1 has potent in vitro antiplasmodial activity, but it is also a DNA intercalator with cytotoxic properties and no correlation was observed between in vitro cytotoxicity and the effect of compounds on the melting point of DNA (DeltaT(m) value) or toxicity in the mouse-malaria model.
The DNA intercalating alkaloid cryptolepine interferes with topoisomerase II and inhibits primarily DNA synthesis in B16 melanoma cells.
- K. Bonjean, M. De Pauw‐Gillet, L. Angenot
- Biology, ChemistryBiochemistry
- 19 March 1998
Direct evidence is provided that DNA is the primary target of cryptolepine and it is suggested that this alkaloid is a valid candidate for the development of tumor active compounds.
Screening of Tanzanian medicinal plants against Plasmodium falciparum and human immunodeficiency virus.
- S. Maregesi, S. Van Miert, L. Pieters
- Biology, MedicinePlanta Medica
- 2010
Medicinal plants used to treat infectious diseases in Bunda district, Tanzania, were screened for activity against Plasmodium falciparum and Human Immunodeficiency Virus Type 1 and Type 2, and only a few extracts were active against HIV-2.
Antiplasmodial activities of some Ghanaian plants traditionally used for fever/malaria treatment and of some alkaloids isolated from Pleiocarpa mutica; in vivo antimalarial activity of pleiocarpine.
- J. Addae-Kyereme, S. Croft, H. Kendrick, C. Wright
- Medicine, BiologyJournal of Ethnopharmacology
- 1 June 2001
Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions
- P. Rasoanaivo, C. Wright, M. Willcox, B. Gilbert
- BiologyMalaria Journal
- 15 March 2011
Positive interactions between components of whole plant extracts may explain evidence that crude plant extracts often have greater in vitro or/and in vivo antiplasmodial activity than isolated constituents at an equivalent dose.
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