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Gene transfer into normal and atherosclerotic human blood vessels.
- M. Rekhter, R. Simari, C. Work, G. Nabel, E. Nabel, D. Gordon
- Biology, Medicine
- Circulation research
- 29 June 1998
Gene transfer to blood vessels is a promising new approach to the treatment of the vascular diseases, but the feasibility of gene transfer to adult human vessels has not been explored. We introduced… Expand
Animal model that mimics atherosclerotic plaque rupture.
Atherosclerotic plaque rupture is the main cause of coronary thrombosis and myocardial infarcts. Currently, there is no animal model of plaque disruption. We have developed a rabbit model in which an… Expand
Properties of adenotin reconstituted into phospholipid vesicles.
Adenotin is a low affinity adenosine binding protein that has amino terminal homology with mammalian and avian stress proteins. Human placental adenotin was solubilized and reconstituted into… Expand
Partial separation of platelet and placental adenosine receptors from adenosine A2-like binding protein.
The ubiquitous adenosine A2-like binding protein obscures the binding properties of adenosine receptors assayed with 5'-N-[3H]ethylcarboxamidoadenosine [( 3H]NECA). To solve this problem, we… Expand
Characteristics of an adenosine A1 binding site in human placental membranes.
- C. Work, K. Hutchison, M. Prasad, R. F. Bruns, I. Fox
- Chemistry, Medicine
- Archives of biochemistry and biophysics
Binding sites were solubilized from human placental membrane using 1.5% sodium cholate and were assayed using polyethylene glycol precipitation. These soluble binding sites had properties of an… Expand
Graft permeabilization facilitates gene therapy of transplant arteriosclerosis in a rabbit model.
BACKGROUND Smooth muscle cell (SMC) replication plays a central role in the pathogenesis of transplant arteriosclerosis. One strategy to eliminate dividing cells is to express a herpesvirus thymidine… Expand
Adenotin and adenotin-like proteins coexist with adenosine receptors in mammalian tissues.
- C. Work, S. Zołnierowicz, K. A. Hutchinson, M. Prasad, I. Fox
- Biology, Medicine
- The Journal of laboratory and clinical medicine
- 1 March 1991
The relationship of adenotin, a low-affinity adenosine-binding protein, to adenosine receptors was examined in two human tissues and two mammalian cultured cell lines. An adenosine A2 receptor exists… Expand
Longitudinal stretch and pressure facilitate gene transfer into rabbit aortic media without endothelial denudation
Cephalosporin-Tobramycin Activity Against Enterococci
Anti-enterococcal synergism was readily demonstrable when cefazolin or cephalothin were combined with gentamicin or tobramycin, and Str. faecalis isolates were killed rapidly at attainable serum… Expand