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An Inhibitory Antibody Blocks Interactions between Components of the Malarial Invasion Machinery
Host cell invasion by apicomplexan pathogens such as the malaria parasite Plasmodium spp. and Toxoplasma gondii involves discharge of proteins from secretory organelles called micronemes andExpand
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Malaria Parasite cGMP-dependent Protein Kinase Regulates Blood Stage Merozoite Secretory Organelle Discharge and Egress
The malaria parasite replicates within an intraerythrocytic parasitophorous vacuole (PV). Eventually, in a tightly regulated process called egress, proteins of the PV and intracellular merozoiteExpand
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Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogens
Apical membrane antigen‐1 (AMA1) is a conserved apicomplexan protein that plays an important but undefined role in host cell invasion. We have studied the fate of Plasmodium falciparum AMA1 (PfAMA1)Expand
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Proteolytic Processing and Primary Structure ofPlasmodium falciparum Apical Membrane Antigen-1*
Plasmodium falciparum apical membrane antigen-1 (PfAMA-1) is a malaria merozoite integral membrane protein that plays an essential but poorly understood role in invasion of host erythrocytes. TheExpand
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Maturation and Specificity of Plasmodium falciparum Subtilisin-like Protease-1, a Malaria Merozoite Subtilisin-like Serine Protease*
Plasmodium falciparum subtilisin-like protease-1 (PfSUB-1) is a protein belonging to the subtilisin-like superfamily of serine proteases (subtilases). PfSUB-1 undergoes extensive posttranslationalExpand
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Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle
The malaria parasite Plasmodium falciparum replicates in an intraerythrocytic parasitophorous vacuole (PV). The most abundant P. falciparum PV protein, called SERA5, is essential in blood stages andExpand
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Crystal Structure of the Malaria Vaccine Candidate Apical Membrane Antigen 1
Apical membrane antigen 1 from Plasmodium is a leading malaria vaccine candidate. The protein is essential for host-cell invasion, but its molecular function is unknown. The crystal structure of theExpand
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Juxtamembrane Shedding of Plasmodium falciparum AMA1 Is Sequence Independent and Essential, and Helps Evade Invasion-Inhibitory Antibodies
The malarial life cycle involves repeated rounds of intraerythrocytic replication interspersed by host cell rupture which releases merozoites that rapidly invade fresh erythrocytes. Apical membraneExpand
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Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery
Cyclic AMP (cAMP) is an important signalling molecule across evolution, but its role in malaria parasites is poorly understood. We have investigated the role of cAMP in asexual blood stageExpand
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Essentiality of Plasmodium falciparum plasmepsin V
The malaria parasite replicates within erythrocytes. The pathogenesis of clinical malaria is in large part due to the capacity of the parasite to remodel its host cell. To do this, intraerythrocyticExpand
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