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Limiting light‐induced lipid peroxidation and vitamin loss in infant parenteral nutrition by adding multivitamin preparations to Intralipid
- KM Silvers, KB Sluis, B. Darlow, F. McGill, R. Stocker, C. Winterbourn
- BiologyActa paediatrica
- 1 March 2001
Multivitamin preparations (MVIP or Soluvit/Vitlipid) inhibited peroxide formation almost completely, and were fully protective when used with dark tubing, while ascorbate loss was seen in the absence of Intralipid and is due to riboflavin‐induced photo‐oxidation.
The relationship of selenium status to respiratory outcome in the very low birth weight infant.
This study demonstrates for the first time in human infants that low plasma selenium levels are significantly associated with an increased respiratory morbidity.
Vitamin C is reduced in human milk after storage
Total vitamin C levels decreased on average by one‐third in the refrigerator or after 1 mo of freezing, with wide variations between individuals (6 to 76% and 3 to 100%, respectively).
Lipid peroxide and hydrogen peroxide formation in parenteral nutrition solutions containing multivitamins.
It is concluded that multivitamins protect Intralipid against lipid peroxidation, but light-dependent hydrogen peroxide production and ascorbate loss occur.
Plasma vitamin A levels in the very low birthweight infant--relationship to respiratory outcome.
Oxidation of parenteral lipid emulsion by ambient and phototherapy lights: potential toxicity of routine parenteral feeding.
The effect of selenium supplementation on outcome in very low birth weight infants: a randomized controlled trial. The New Zealand Neonatal Study Group.
Early ascorbic acid depletion is related to the severity of acute pancreatitis
Whether plasma AA concentration continues to decrease after admission and whether the extent of decrease is related to the severity of pancreatitis is investigated.
The correlation of elevated levels of an index of lipid peroxidation (MDA‐TBA) with adverse outcome in the very low birthweight infant
MDA‐TBA levels appear to be a useful measure to continue to explore the role of free radical mediated disease in the VLBW infant and support the hypothesis that oxidative injury, particularly within the first 7 days of life, is associated with the development of the long‐term complications of the pre‐term infant.
Vitamin C supplementation in very preterm infants: a randomised controlled trial
- B. Darlow, H. Buss, F. McGill, L. Fletcher, P. Graham, C. Winterbourn
- MedicineArchives of Disease in Childhood - Fetal and…
- 1 March 2005
In a randomised controlled trial, no significant benefits or harmful effects were associated with treatment allocation to higher or lower AA supplementation throughout the first 28 days of life.