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Formation of cyclic adducts of deoxyguanosine with the aldehydes trans-4-hydroxy-2-hexenal and trans-4-hydroxy-2-nonenal in vitro.
T-4HH and t-4HN possess the ability to alkylate deoxyguanosine in vitro and suggest possible mechanisms for 4-hydroxyalkenal and pyrrolizidine alkaloid genotoxicity.
Environmental Toxicology.Cambridge Environmental Chemistry Series, Volume 11.ByDavid A Wrightand, Pamela Welbourn.Cambridge and New York: Cambridge University Press. $150.00 (hardcover); $55.00…
- C. Winter
- 1 March 2004
Risk of salmonellosis from consumption of almonds in the North American market
The current regulation of mandatory treatment of almonds sold in North America is effective in maintaining the risk of salmonellosis from consumption of almonds below an arithmetic mean of 1 case/year, although significant increases in either prevalence or concentration, or small increases in proportion of untreated almonds would frequently lead to exceeding this threshold.
Diacetyl in Foods: A Review of Safety and Sensory Characteristics
Diacetyl, noted for its appealing butter-like aroma, is present naturally in many foods, and humans have been exposed to it since the beginning of civilization, but consumer dietary exposure to diacetyl in foods is below levels of health concern while common airborne levels of di acetyl from MW popcorn are far below the conservatively established limit to protect workers.
Comparison of acrylamide intake from Western and guideline based diets using probabilistic techniques and linear programming.
- J. Katz, C. Winter, S. Buttrey, J. Fadel
- MedicineFood and chemical toxicology : an international…
- 1 March 2012
This is believed to be the first example of a risk assessment that combines probabilistic techniques with linear programming and results demonstrate that linear programming techniques can be used to model specific diets for the assessment of toxicological and nutritional dietary components.
Quantitative microbial risk assessment for Staphylococcus aureus and Staphylococcus enterotoxin A in raw milk.
This study illustrates the utility of quantitative microbial risk assessments for identifying potential food safety issues and predicted that exposure at the 99.99th percentile could represent a dose capable of eliciting staphylococcal enterotoxin intoxication in all consumer age groups.
Distribution of trans-4-hydroxy-2-hexenal and tandem mass spectrometric detection of its urinary mercapturic acid in the rat.
- C. Winter, H. Segall, A. D. Jones
- Chemistry, MedicineDrug metabolism and disposition: the biological…
- 1 September 1987
A tandem mass spectrometry technique using negative ion fast atom bombardment (FAB) ionization in combination with Mass-analyzed Ion Kinetic Energy Spectrometry verified that a C-3 mercapturic acid conjugate of trans-4-hydroxy-2-hexenal was produced as a urinary metabolite.
Biosynthetic Studies of Fumonisin B1 and AAL Toxins
The biosynthesis of the sphinganine analogue mycotoxins (SAMs) fumonisin B1 and the AAL toxins was studied by growing Fusarium moniliforme and Alternaria alternata f. sp. lycopersici in liquid…
Impact of atmospheric pollution on linear furanocoumarin content in celery
A single 4-hr acidic fog at pH levels associated with commercial celery production near major population centers in California was found to stimulate development of psoralen, bergapten, xanthotoxin, and isopimpinellin within 24 hr and for at least 120 hr after exposure.
Electrospray Ionization Mass Spectrometry of Sphinganine Analog Mycotoxins
The ionization and differentation behavior of two groups of sphinganine analog mycotoxins (SAMs), the AAL toxins (TA, TB, TC, TD, and TE) and fumonisins (FB 1 and FB 2 ), were compared in positive…