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Behavioral models of impulsivity in relation to ADHD: Translation between clinical and preclinical studies
TLDR
This review describes and evaluates some of the current behavioral models of impulsivity developed for use with rodents based on human neuropsychological tests, focusing on the five-choice serial reaction time task, the stop-signal reaction timetask and delay-discounting paradigms. Expand
Contrasting Roles of Basolateral Amygdala and Orbitofrontal Cortex in Impulsive Choice
TLDR
This is the first time that lesions to these two structures have produced opposite behavioral effects, indicating their distinct contributions to cognition. Expand
Fractionating Impulsivity: Contrasting Effects of Central 5-HT Depletion on Different Measures of Impulsive Behavior
TLDR
Not all measures of impulsivity appear to be uniformly affected by 5-HT depletion, or correlate with each other, supporting the suggestion that impulsivity is not a unitary construct. Expand
Serotonergic and Dopaminergic Modulation of Gambling Behavior as Assessed Using a Novel Rat Gambling Task
TLDR
The data suggest that both serotonergic and dopaminergic agents can impair and improve gambling performance, and indicate that the rGT will be a useful tool to study the biological basis of gambling. Expand
Global 5-HT depletion attenuates the ability of amphetamine to decrease impulsive choice on a delay-discounting task in rats
TLDR
The ability of amphetamine to decrease impulsivity is not solely due to its effects on dopaminergic systems, but may also depend on serotonergic neurotransmission. Expand
5-HT2A and 5-HT2C receptor antagonists have opposing effects on a measure of impulsivity: interactions with global 5-HT depletion
TLDR
Data support the view that serotonergic regulation of impulsive behaviour through different members of the 5-HT2 receptor family is functionally heterogeneous. Expand
Limbic Corticostriatal Systems and Delayed Reinforcement
TLDR
Impulsive choice is characterized by an abnormally high preference for small, immediate rewards over larger delayed rewards, and can be a feature of adolescence, but also attention‐deficit/hyperactivity disorder (ADHD), addiction, and other neuropsychiatric disorders. Expand
Contributions of the orbitofrontal cortex to impulsive choice: interactions with basal levels of impulsivity, dopamine signalling, and reward-related cues
TLDR
Providing explicit environmental cues to signal the delay-to-reinforcement appears to change the way in which the orbitofrontal cortex is recruited in the decision-making process in a baseline-dependent fashion. Expand
Intra-prefrontal 8-OH-DPAT and M100907 improve visuospatial attention and decrease impulsivity on the five-choice serial reaction time task in rats
TLDR
Results indicate that modulation of 5-HT function within the mPFC via distinct receptors can enhance performance on the 5CSRT, and suggest a mechanism by which serotonergic agents improve cognitive function. Expand
Cortico-limbic-striatal circuits subserving different forms of cost-benefit decision making
TLDR
Recent studies in rodents investigating the contribution of amygdala and nucleus accumbens systems to different forms of cost-benefit decision making and focus on evaluations related to delays, effort, or risks associated with certain rewards. Expand
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