C. Winkelman

Publications101
h-index25
Citations3,847
Highly Influential Citations215
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Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU
TLDR
Substantial agreement was found among a large, interdisciplinary cohort of international experts regarding evidence supporting recommendations, and the remaining literature gaps in the assessment, prevention, and treatment of Pain, Agitation/sedation, Delirium, Immobility (mobilization/rehabilitation), and Sleep (disruption) in critically ill adults.
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Standardized Rehabilitation and Hospital Length of Stay Among Patients With Acute Respiratory Failure: A Randomized Clinical Trial.
TLDR
Patients in the SRT group received daily therapy until hospital discharge, consisting of passive range of motion, physical therapy, and progressive resistance exercise, and there was no difference in duration of ventilation or ICU care.
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An official American Thoracic Society Clinical Practice guideline: the diagnosis of intensive care unit-acquired weakness in adults.
TLDR
Research that identifies treatments that benefit patients with ICUAW is necessary to determine whether the benefits of diagnostic testing forICUAW outweigh its burdens.
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Receiving Early Mobility During an Intensive Care Unit Admission Is a Predictor of Improved Outcomes in Acute Respiratory Failure
TLDR
Tracheostomy, female gender, higher Charlson Comorbidity Index and lack of early ICU mobility were associated with readmissions or death during the first year, although the mechanisms of increased hospital readmission are unclear.
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Inactivity and inflammation in the critically ill patient.
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Activity in the Chronically Critically Ill
TLDR
Typical therapeutic activity is described and acceptable agreement between the two measures of activity for both frequency and duration of therapeutic but not for type of activity is demonstrated.
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The role of inflammation in ICU-acquired weakness
TLDR
The authors suggest systemic, inflammatory-mediated pathology is the most significant risk factor for ICU-AW and this finding provides important direction for future investigations and illustrates the challenges of interpreting significance in small observational studies.
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Executive Summary: Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU.
Author(s): Devlin, John W; Skrobik, Yoanna; Gelinas, Celine; Needham, Dale M; Slooter, Arjen JC; Pandharipande, Pratik P; Watson, Paula L; Weinhouse, Gerald L; Nunnally, Mark E; Rochwerg, Bram;…
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Bed Rest in Health and Critical Illness: A Body Systems Approach
TLDR
This review uses body systems to cluster classic and current results of bed rest studies, beginning with cardiovascular and including pulmonary, renal, skin, nervous, immune, gastrointestinal/ metabolic, and skeletal systems, and concludes with effects on muscles.
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Inactivity and inflammation: selected cytokines as biologic mediators in muscle dysfunction during critical illness.
Muscle dysfunction leads to activity intolerance, prolonged hospitalization, and additional days of mechanical ventilation. The etiology of muscle dysfunction in the critically ill patient is…
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