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cGMP‐mediated phosphorylation of heat shock protein 20 may cause smooth muscle relaxation without myosin light chain dephosphorylation in swine carotid artery
1 Nitrovasodilators such as nitroglycerine, via production of nitric oxide and an increase in [cGMP], can induce arterial smooth muscle relaxation without proportional reduction in myosin light chainExpand
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Multi-walled carbon nanotube instillation impairs pulmonary function in C57BL/6 mice
BackgroundMulti-walled carbon nanotubes (MWCNTs) are widely used in many disciplines due to their unique physical and chemical properties. Therefore, some concerns about the possible human health andExpand
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Effects of increased muscle mass on mouse sagittal suture morphology and mechanics.
The purpose of this study is to test predicted form-function relationships between cranial suture complexity and masticatory muscle mass and biomechanics in a mouse model. Specifically, to test theExpand
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Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway
Relaxation of the smooth muscle cells in the cavernosal arterioles and sinuses results in increased blood flow into the penis, raising corpus cavernosum pressure to culminate in penile erection.Expand
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Ultrafine particulate matter exposure augments ischemia-reperfusion injury in mice.
Epidemiological studies have linked ambient particulate matter (PM) levels to an increased incidence of adverse cardiovascular events. Yet little is definitively known about the mechanisms accountingExpand
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Altered penile vascular reactivity and erection in the Zucker obese-diabetic rat.
INTRODUCTION The combination of the independent risk factors for erectile dysfunction, obesity, hypertension, and diabetes are manifested collectively in a condition known as metabolic syndrome X.Expand
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Novel murine model of chronic granulomatous lung inflammation elicited by carbon nanotubes.
Lung granulomas are associated with numerous conditions, including inflammatory disorders, exposure to environmental pollutants, and infection. Osteopontin is a chemotactic cytokine produced byExpand
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Cooperative attachment of cross bridges predicts regulation of smooth muscle force by myosin phosphorylation.
Serine 19 phosphorylation of the myosin regulatory light chain (MRLC) appears to be the primary determinant of smooth muscle force development. The relationship between MRLC phosphorylation and forceExpand
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A carbon nanotube toxicity paradigm driven by mast cells and the IL-₃₃/ST₂ axis.
Concern about the use of nanomaterials has increased significantly in recent years due to potentially hazardous impacts on human health. Mast cells are critical for innate and adaptive immuneExpand
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Mast cells contribute to altered vascular reactivity and ischemia-reperfusion injury following cerium oxide nanoparticle instillation
Abstract Cerium oxide (CeO2) represents an important nanomaterial with wide ranging applications. However, little is known regarding how CeO2 exposure may influence pulmonary or systemicExpand
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