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The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.
Toll-like receptors (TLRs) have been shown to participate in the recognition of pathogens by the innate immune system, but it is not clear how a restricted family of receptors has the capacity toExpand
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A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.
The role of DNA methylation and of the maintenance DNA methyltransferase Dnmt1 in the epigenetic regulation of developmental stage- and cell lineage-specific gene expression in vivo is uncertain.Expand
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The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
Macrophages orchestrate innate immunity by phagocytosing pathogens and coordinating inflammatory responses. Effective defence requires the host to discriminate between different pathogens. TheExpand
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Regulation of interferon-gamma during innate and adaptive immune responses.
Interferon-gamma (IFN-gamma) is crucial for immunity against intracellular pathogens and for tumor control. However, aberrant IFN-gamma expression has been associated with a number ofExpand
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Human Toll-like receptor 4 recognizes host-specific LPS modifications
Lipopolysaccharide (LPS) is the principal proinflammatory component of the Gram-negative bacterial envelope and is recognized by the Toll-like receptor 4 (TLR4)–MD-2 receptor complex. Bacteria canExpand
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Epigenetic control of T-helper-cell differentiation
Naive CD4+ T cells give rise to T-helper-cell subsets with functions that are tailored to their respective roles in host defence. The specification of T-helper-cell subsets is controlled by networksExpand
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Cutting Edge: Functional Interactions Between Toll-Like Receptor (TLR) 2 and TLR1 or TLR6 in Response to Phenol-Soluble Modulin1
Toll-like receptor (TLR) 2 and TLR4 play important roles in the early, innate immune response to microbial challenge. TLR2 is preferentially involved in the inflammatory response to lipoteichoicExpand
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Neonatal Innate TLR-Mediated Responses Are Distinct from Those of Adults1
The human neonate and infant are unduly susceptible to infection with a wide variety of microbes. This susceptibility is thought to reflect differences from adults in innate and adaptive immunity,Expand
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DNA Hypomethylation Perturbs the Function and Survival of CNS Neurons in Postnatal Animals
DNA methyltransferase I (Dnmt1), the maintenance enzyme for DNA cytosine methylation, is expressed at high levels in the CNS during embryogenesis and after birth. Because embryos deficient for Dnmt1Expand
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Cloning two isoforms of rat cyclooxygenase: differential regulation of their expression.
  • L. Feng, W. Sun, +5 authors D. Hwang
  • Biology, Medicine
  • Archives of biochemistry and biophysics
  • 1 December 1993
Two isoforms of cyclooxygenase (COX) have been identified in eukaryotic cells: COX-1 encoded by a 2.8-kb mRNA, and a mitogen-inducible COX-2 encoded by a 4-kb mRNA. We have cloned the COX-1 and COX-2Expand
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