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The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.
The data suggest that TLRs sample the contents of the phagosome independent of the nature of the contents, and can establish a combinatorial repertoire to discriminate among the large number of pathogen-associated molecular patterns found in nature. Expand
A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.
It is concluded that Dnmt1 and DNA methylation are required for the proper expression of certain genes that define fate and determine function in T cells. Expand
Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains
The significant quantitative and qualitative variations in abnormal immunologic expression suggest that different constellations of factors, genetic and/or pathophysiologic, may operate in the three murine strains and that each constellation is capable of leading to the activation of common immunopathologic effector mechanisms that cause quite similar SLE-like syndromes. Expand
Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial.
An analysis of prognostic factors indicates that the initial performance status, age, the use of only a surgical biopsy, parietal location, the presence of seizures, or the involvement of cranial nerves II, III, IV, and VI are all of significance. Expand
Diagnosis and management of pituitary abscess: a review of twenty-four cases.
Antibiotic therapy is suggested for patients who have symptoms of sepsis, or for patients in whom specific organisms are identified from cultures obtained during surgery, and the transsphenoidal approach is recommended over open craniotomy for surgical drainage. Expand
Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery.
It is suggested that it is best to use radiotherapy in the post-surgical treatment of malignant glioma and to continue the search for an effective chemotherapeutic regimen to use in addition to radiotherapy. Expand
Cloning two isoforms of rat cyclooxygenase: differential regulation of their expression.
  • L. Feng, W. Sun, +5 authors D. Hwang
  • Biology, Medicine
  • Archives of biochemistry and biophysics
  • 1 December 1993
The two COX isoforms were differentially expressed, and COX-2 was selectively induced in response to inflammatory stimuli in rats, suggesting that the brain among tissues tested exhibits basal expression of COx-2 as the major form of the enzyme. Expand
Positionally independent and exchangeable late budding functions of the Rous sarcoma virus and human immunodeficiency virus Gag proteins
The remarkable finding that the late assembly domains from these two unrelated Gag proteins are exchangeable between retroviruses and can function in a positionally independent manner is demonstrated. Expand
An assembly domain of the Rous sarcoma virus Gag protein required late in budding
The location of assembly domain 2 (AD2) within the proline-rich p2b sequence of this Gag protein is established, establishing the idea that AD2 is a dynamic region of movement, perhaps serving as a molecular hinge to allow the particle to emerge from the surface of the cell during budding. Expand
Inhibition of constitutive nitric oxide synthase (NOS) by nitric oxide generated by inducible NOS after lipopolysaccharide administration provokes renal dysfunction in rats.
Findings suggest that the decrease in GFR after LPS is due to local inhibition of eNOS by iNOS, possibly via NO autoinhibition. Expand