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Proteomic characterization of the human centrosome by protein correlation profiling
TLDR
A mass-spectrometry-based proteomic analysis of human centrosomes in the interphase of the cell cycle by quantitatively profiling hundreds of proteins across several centrifugation fractions identified and validated 23 novel components and identified 41 likely candidates as well as the vast majority of the known centrosomal proteins in a large background of nonspecific proteins. Expand
The Polo kinase Plk4 functions in centriole duplication
TLDR
It is identified that Plk4 is required — in cooperation with Cdk2, CP110 and Hs-SAS6 — for the precise reproduction of centrosomes during the cell cycle and this findings provide an attractive explanation for the crucial function of PlK4 in cell proliferation. Expand
Rootletin forms centriole-associated filaments and functions in centrosome cohesion
TLDR
The ability of rootletin to form centriole-associated fibers suggests a dynamic model for centrosome cohesion based on entangling filaments rather than continuous polymeric linkers. Expand
Centrosome-associated Chk1 prevents premature activation of cyclin-B–Cdk1 kinase
TLDR
It is suggested that centrosome-associated Chk1 shields centrosomal Cdk1 from unscheduled activation by cytoplasmic Cdc25B, thereby contributing to proper timing of the initial steps of cell division, including mitotic spindle formation. Expand
Polarization and orientation of retinal ganglion cells in vivo
TLDR
Four-dimensional microscopy of developing retinal ganglion cells (RGCs) in live zebrafish embryos indicates that extrinsic factors such as access to the basal lamina are critical for normal axon emergence from RGCs in vivo. Expand
The centriolar satellite proteins Cep72 and Cep290 interact and are required for recruitment of BBS proteins to the cilium
TLDR
A new component of satellites, Cep72, is identified and its role in the regulation of Cep290 and BBS4 is described, as are developmental defects resulting from loss of satellites in zebrafish. Expand
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4
TLDR
These findings help establish the link between centrosome function, tissue architecture and transcriptional control in the pathogenesis of cystic kidney disease, retinal degeneration, and central nervous system development. Expand
Cep70 and Cep131 contribute to ciliogenesis in zebrafish embryos
TLDR
It is proposed that the role of these centrosomal/basal body proteins is in making the cilium and that they are involved in determination of the length of the axoneme in zebrafish embryos. Expand
Microcephaly models in the developing zebrafish retinal neuroepithelium point to an underlying defect in metaphase progression
TLDR
Imaging studies reveal a dramatic rise in the fraction of proliferating cells in mitosis in all cases, and time-lapse microscopy points to a failure of progression through prometaphase, which appears to be secondary to the mitotic defect. Expand
Identifying an uptake mechanism for the antiepileptic and bipolar disorder treatment valproic acid using the simple biomedical model Dictyostelium
TLDR
A range of cellular, molecular and genetic approaches are employed to characterize VPA uptake using a simple biomedical model, Dictyostelium discoideum, and implicate, for the first time, an uptake mechanism for VPA through SLC4-catalysed activity. Expand
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