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Pathogen Entrapment by Transglutaminase—A Conserved Early Innate Immune Mechanism
The results firmly establish the hemolymph/blood clot as an important effector of early innate immunity, which helps to prevent septic infections and will help to guide further strategies to reduce the damaging effects of clotting and enhance its beneficial contribution to immune reactions. Expand
Fondue and transglutaminase in the Drosophila larval clot.
A Fondue-GFP fusion construct that labels the cuticle and clot is described, and it is shown that chemical inhibition and RNAi knockdown of the Drosophila transglutaminase gene affect clot properties and composition in ways similar to knock down of the fon gene. Expand
Clotting Factors and Eicosanoids Protect against Nematode Infections
We show that hemolymph clotting protects Drosophila melanogaster against infections with an entomopathogenic nematode and its symbiotic bacterium. We also provide biochemical and genetic evidence forExpand
Serotonin 5-HT2A Receptor Binding in Platelets From Patients With Alzheimer's Disease or Vascular Dementia
The study indicates that platelet 5-HT2A receptor status is of limited value as a peripheral marker in dementia. Expand
The Binax NOW Test as a Tool for Diagnosis of Severe Acute Otitis Media and Associated Complications
It was showed that the Binax NOW test is a useful diagnostic tool for patients with severe AOM with or without complications, and it was easily adapted to bone tissue. Expand
Proteomics of the Drosophila hemolymph clot and the function of transglutaminase
Insects rely on a fast and effective coagulation and wound response to avoid loss of body fluids and immobilize pathogens. Arthropod coagulation is in some respect equivalent to vertebrate coagulatExpand