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ConsensusPathDB—a database for integrating human functional interaction networks
ConsensusPathDB is a database system for the integration of human functional interactions. Current knowledge of these interactions is dispersed in more than 200 databases, each having a specificExpand
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ConsensusPathDB: toward a more complete picture of cell biology
ConsensusPathDB is a meta-database that integrates different types of functional interactions from heterogeneous interaction data resources. Physical protein interactions, metabolic and signalingExpand
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Systems Biology in Practice: Concepts, Implementation and Application
Preface. Foreword. Part I: General Introduction. 1. Basic Principles. 2. Biology in a Nutshell. 3. Mathematics in a Nutshell. 4. Experimental Techniques in a Nutshell. Part II: Standard Models andExpand
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Systems Biology - a Textbook
INTRODUCTION TO SYSTEMS BIOLOGY Introduction Modeling of Biochemical Systems Specific Biochemical Systems Model Fitting Analysis of High-throughput Data Gene Expression Models Stochastic Systems andExpand
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Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells
Inhibition of Hedgehog (HH)/GLI signalling in cancer is a promising therapeutic approach. Interactions between HH/GLI and other oncogenic pathways affect the strength and tumourigenicity of HH/GLI.Expand
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Systems Biology in Practice
An apparatus for flattening thin metal cans is disclosed wherein the can is first creased or notched to incline the can ends with respect to the can axis and each can end is then folded about an axisExpand
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Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors
Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours responding to available therapies, requiring a better molecular understanding of the disease in precisionExpand
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The structural impact of cancer-associated missense mutations in oncogenes and tumor suppressors
BackgroundCurrent large-scale cancer sequencing projects have identified large numbers of somatic mutations covering an increasing number of different cancer tissues and patients. However, theExpand
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Monte Carlo analysis of an ODE Model of the Sea Urchin Endomesoderm Network
BackgroundGene Regulatory Networks (GRNs) control the differentiation, specification and function of cells at the genomic level. The levels of interactions within large GRNs are of enormous depth andExpand
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Primary Differentiation in the Human Blastocyst: Comparative Molecular Portraits of Inner Cell Mass and Trophectoderm Cells
The primary differentiation event during mammalian development occurs at the blastocyst stage and leads to the delineation of the inner cell mass (ICM) and the trophectoderm (TE). We provide theExpand
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