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The expanding knowledge of TLR4 specificity and its downstream signaling pathways should provide new opportunities for blocking inflammation associated with infection.
Biosynthesis and assembly of capsular polysaccharides in Escherichia coli.
- C. Whitfield
- BiologyAnnual review of biochemistry
- 6 June 2006
In gram-negative bacteria, it is proposed that biosynthesis and translocation of capsular polysaccharides to the cell surface are temporally and spatially coupled by multiprotein complexes that span the cell envelope.
Structure, assembly and regulation of expression of capsules in Escherichia coli
A new classification system is provided that separates the known capsules of E. coli into four distinct groups, taking into account the organization of capsule gene clusters, details of the assembly pathway, and regulatory features that dictate capsule expression.
Biosynthesis and export of bacterial lipopolysaccharides.
This work reviews recent advances in the processes used for lipopolysaccharide biosynthesis and export, emphasizing the reactions that are essential for viability.
Biosynthesis of lipopolysaccharide O antigens.
- C. Whitfield
- ChemistryTrends in microbiology
- 1 May 1995
Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica
Differences in these clusters reflect important structural variations in the outer core oligosaccharides and provide a basis for ascribing functions to the genes in these model clusters, whereas highly conserved regions within these clusters suggest a critical and unalterable function for the inner region of the core.
Distribution of Core Oligosaccharide Types in Lipopolysaccharides from Escherichia coli
- Karen L. Amor, D. Heinrichs, Emilisa Frirdich, K. Ziebell, ROGER P. Johnson, C. Whitfield
- BiologyInfection and Immunity
- 1 March 2000
Unique sequences in the waa (core OS biosynthesis) gene operon were used to develop a PCR-based system that facilitated unequivocal determination of the core OS types in isolates of E. coli.
Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein
A route and mechanism for translocation of the capsular polysaccharide of Wza, an integral outer membrane lipoprotein, which is essential for group 1 capsule export in Escherichia coli is proposed and may provide insight into the export of other large polar molecules such as DNA and proteins.
Pivotal Roles of the Outer Membrane Polysaccharide Export and Polysaccharide Copolymerase Protein Families in Export of Extracellular Polysaccharides in Gram-Negative Bacteria
- L. Cuthbertson, Iain L Mainprize, J. Naismith, C. Whitfield
- BiologyMicrobiology and Molecular Biology Reviews
- 1 March 2009
Proteins in the polysaccharide copolymerase (PCP) family have been implicated in several aspects of polymer biogenesis, but there is unequivocal evidence that PCP and OPX proteins interact to form a trans-envelope scaffold for polymer export.