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Overview of Carboxylesterases and Their Role in the Metabolism of Insecticides
Carboxylesterases hydrolyze numerous endogenous and exogenous ester-containing compounds. They play a role in the detoxification of many agrochemicals including pyrethroids, organophosphates, andExpand
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Identification, Expression, and Purification of a Pyrethroidhydrolyzing Carboxylesterase from Mouse Liver Microsomes*[boxs]
Carboxylesterases are enzymes that catalyze the hydrolysis of a wide range of ester-containing endogenous and xenobiotic compounds. Although the use of pyrethroids is increasing, the specific enzymesExpand
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Influence of container adsorption upon observed pyrethroid toxicity to Ceriodaphnia dubia and Hyalella azteca.
Pyrethroid insecticides are known for their potential toxicity to aquatic invertebrates and many fish species. A significant problem in the study of pyrethroid toxicity is their extremeExpand
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PfEMP1-DBL1α amino acid motifs in severe disease states of Plasmodium falciparum malaria
An infection with Plasmodium falciparum may lead to severe malaria as a result of excessive binding of infected erythrocytes in the microvasculature. Vascular adhesion is mediated by P. falciparumExpand
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Structural refinement of inhibitors of urea-based soluble epoxide hydrolases.
The soluble epoxide hydrolase (sEH) is involved in the metabolism of arachidonic, linoleic, and other fatty acid epoxides, endogenous chemical mediators that play an important role in blood pressureExpand
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Structural studies of a potent insect maturation inhibitor bound to the juvenile hormone esterase of Manduca sexta.
Juvenile hormone (JH) is an insect hormone containing an alpha,beta-unsaturated ester consisting of a small alcohol and long, hydrophobic acid. JH degradation is required for proper insectExpand
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PfEMP1-DBL1alpha amino acid motifs in severe disease states of Plasmodium falciparum malaria.
An infection with Plasmodium falciparum may lead to severe malaria as a result of excessive binding of infected erythrocytes in the microvasculature. Vascular adhesion is mediated by P. falciparumExpand
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Pyrethroid tolerance in Culex pipiens pipiens var molestus from Marin County, California.
In May 2001 a sample of Culex pipiens pipiens variety molestus Forskål from Marin County, California, collected as larvae and reared to adults, was found to show reduced resmethrin and permethrinExpand
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Juvenile hormone (JH) esterase: why are you so JH specific?
Juvenile hormone esterases (JHEs) from six insects belonging to three orders (Lepidoptera, Coleoptera, and Diptera) were compared in terms of their deduced amino acid sequence and biochemicalExpand
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Investigation of the role of a second conserved serine in carboxylesterases via site-directed mutagenesis.
Carboxylesterases are enzymes that catalyze the hydrolysis of ester and amide moieties. These enzymes have an active site that is composed of a nucleophile (Ser), a base (His), and an acid (Glu) thatExpand
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  • Open Access