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The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis
Background:To investigate small-nucleolar RNAs (snoRNAs) as reference genes when measuring miRNA expression in tumour samples, given emerging evidence for their role in cancer.Methods:Four snoRNAs,Expand
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Imaging tumour hypoxia with positron emission tomography
Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its association with an aggressive tumour phenotype and therapeutic resistance. Given its prominent role in oncology,Expand
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The independence of intrinsic radiosensitivity as a prognostic factor for patient response to radiotherapy of carcinoma of the cervix.
A study was made of the prognostic value of pretreatment measurements of tumour radiosensitivity (surviving fraction at 2 Gy, SF2) in 128 patients with stage I-III carcinomas of the uterine cervixExpand
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Genetics and genomics of radiotherapy toxicity: towards prediction
Radiotherapy is involved in many curative treatments of cancer; millions of survivors live with the consequences of treatment, and toxicity in a minority limits the radiation doses that can be safelyExpand
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A high ratio of apoptosis to proliferation correlates with improved survival after radiotherapy for cervical adenocarcinoma.
PURPOSE A retrospective study was made of the role of apoptosis in determining radiotherapy outcome in 39 adenocarcinoma of the cervix. A comparison was also made of the detection of apoptosis byExpand
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High tumor angiogenesis is associated with poorer survival in carcinoma of the cervix treated with radiotherapy.
The purpose of this study was to examine the relationship between tumor angiogenesis and prognosis in carcinoma of the cervix treated with radiotherapy with a median follow-up time of 55 months. AExpand
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Incorporating Genetic Biomarkers into Predictive Models of Normal Tissue Toxicity.
There is considerable variation in the level of toxicity patients experience for a given dose of radiotherapy, which is associated with differences in underlying individual normal tissueExpand
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Tumour oxygenation levels correlate with dynamic contrast-enhanced magnetic resonance imaging parameters in carcinoma of the cervix.
BACKGROUND AND PURPOSE The Eppendorf pO(2) histograph is the 'gold standard' method for measuring tumour oxygenation. The method is not suitable for widespread application because its use is limitedExpand
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Establishment of a Radiogenomics Consortium.
A Radiogenomics Consortium was established in Manchester, United Kingdom November 17–18th 2009 in conjunction with the 15th LH Gray Workshop with investigators from throughout the world participatingExpand
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Expression of Ku70 correlates with survival in carcinoma of the cervix
Cervical carcinoma affects around 3400 women in the UK each year and advanced disease is routinely treated with radiation. As part of a programme to establish rapid and convenient methods ofExpand
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