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The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis
Background:To investigate small-nucleolar RNAs (snoRNAs) as reference genes when measuring miRNA expression in tumour samples, given emerging evidence for their role in cancer.Methods:Four snoRNAs,… Expand
Imaging tumour hypoxia with positron emission tomography
Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its association with an aggressive tumour phenotype and therapeutic resistance. Given its prominent role in oncology,… Expand
The independence of intrinsic radiosensitivity as a prognostic factor for patient response to radiotherapy of carcinoma of the cervix.
A study was made of the prognostic value of pretreatment measurements of tumour radiosensitivity (surviving fraction at 2 Gy, SF2) in 128 patients with stage I-III carcinomas of the uterine cervix… Expand
Genetics and genomics of radiotherapy toxicity: towards prediction
Radiotherapy is involved in many curative treatments of cancer; millions of survivors live with the consequences of treatment, and toxicity in a minority limits the radiation doses that can be safely… Expand
A high ratio of apoptosis to proliferation correlates with improved survival after radiotherapy for cervical adenocarcinoma.
PURPOSE A retrospective study was made of the role of apoptosis in determining radiotherapy outcome in 39 adenocarcinoma of the cervix. A comparison was also made of the detection of apoptosis by… Expand
High tumor angiogenesis is associated with poorer survival in carcinoma of the cervix treated with radiotherapy.
- R. Cooper, D. Wilks, +4 authors C. West
- Clinical cancer research : an official journal of…
- 1 November 1998
The purpose of this study was to examine the relationship between tumor angiogenesis and prognosis in carcinoma of the cervix treated with radiotherapy with a median follow-up time of 55 months. A… Expand
Incorporating Genetic Biomarkers into Predictive Models of Normal Tissue Toxicity.
- G. Barnett, S. Kerns, D. Noble, A. Dunning, C. West, N. Burnet
- Clinical oncology (Royal College of Radiologists…
- 1 October 2015
There is considerable variation in the level of toxicity patients experience for a given dose of radiotherapy, which is associated with differences in underlying individual normal tissue… Expand
Tumour oxygenation levels correlate with dynamic contrast-enhanced magnetic resonance imaging parameters in carcinoma of the cervix.
- R. Cooper, B. Carrington, +8 authors C. West
- Radiotherapy and oncology : journal of the…
- 1 October 2000
BACKGROUND AND PURPOSE The Eppendorf pO(2) histograph is the 'gold standard' method for measuring tumour oxygenation. The method is not suitable for widespread application because its use is limited… Expand
Establishment of a Radiogenomics Consortium.
- C. West, B. Rosenstein, +34 authors J. Yarnold
- International journal of radiation oncology…
- 1 April 2010
A Radiogenomics Consortium was established in Manchester, United Kingdom November 17–18th 2009 in conjunction with the 15th LH Gray Workshop with investigators from throughout the world participating… Expand
Expression of Ku70 correlates with survival in carcinoma of the cervix
- C. Wilson, S. Davidson, G. Margison, S. Jackson, J. Hendry, C. West
- Biology, Medicine
- British Journal of Cancer
- 1 December 2000
Cervical carcinoma affects around 3400 women in the UK each year and advanced disease is routinely treated with radiation. As part of a programme to establish rapid and convenient methods of… Expand