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MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
The cytokine macrophage migration inhibitory factor (MIF) plays a critical role in inflammatory diseases and atherogenesis. We identify the chemokine receptors CXCR2 and CXCR4 as functional receptorsExpand
Atherosclerosis: current pathogenesis and therapeutic options
Coronary artery disease (CAD) arising from atherosclerosis is a leading cause of death and morbidity worldwide. The underlying pathogenesis involves an imbalanced lipid metabolism and a maladaptiveExpand
Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection
Apoptotic endothelial cells release microRNA-containing microvesicles to modulate the responses of neighboring cells and reduce atherosclerosis in mice. Sounding the Alarm In addition to itsExpand
Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E
We studied whether circulating activated platelets and platelet–leukocyte aggregates cause the development of atherosclerotic lesions in apolipoprotein-E–deficient (Apoe−/−) mice. CirculatingExpand
JAM-1 is a ligand of the β2 integrin LFA-1 involved in transendothelial migration of leukocytes
Inflammatory recruitment of leukocytes is governed by dynamic interactions between integrins and endothelial immunoglobulin superfamily (IgSF) proteins. We have identified the IgSF member junctionalExpand
Microparticles: Protagonists of a Novel Communication Network for Intercellular Information Exchange
Microparticles represent a heterogeneous population of vesicles with a diameter of 100 to 1000 nm that are released by budding of the plasma membrane and express antigens specific of their parentalExpand
Endothelial progenitor cells: characterization, pathophysiology, and possible clinical relevance
  • M. Hristov, C. Weber
  • Biology, Medicine
  • Journal of cellular and molecular medicine
  • 1 October 2004
Bone marrow and peripheral blood of adults contain a special sub‐type of progenitor cells which are able to differentiate into mature endothelial cells, thus contributing to re‐endothelialization andExpand
Differential chemokine receptor expression and function in human monocyte subpopulations
The subset of human blood monocytes expressing low levels of CD14 and high levels of CD16 (CD14+CD16+) exhibits features resembling mature tissue macrophages and can be expanded in inflammatoryExpand
Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance
Unique among leukocytes, neutrophils follow daily cycles of release from and migration back into the bone marrow, where they are eliminated. Because removal of dying cells generates homeostaticExpand
Platelets as Immune Cells: Bridging Inflammation and Cardiovascular Disease
Beyond an eminent role in hemostasis and thrombosis, platelets are characterized by expert functions in assisting and modulating inflammatory reactions and immune responses. This is achieved by theExpand
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