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Crystal Structure of a β-Catenin/Tcf Complex
Abstract The Wnt signaling pathway plays critical roles in embryonic development and tumorigenesis. Stimulation of the Wnt pathway results in the accumulation of a nuclear β-catenin/Tcf complex,Expand
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Crystal structure of a beta-catenin/Tcf complex.
The Wnt signaling pathway plays critical roles in embryonic development and tumorigenesis. Stimulation of the Wnt pathway results in the accumulation of a nuclear beta-catenin/Tcf complex, activatingExpand
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Interaction among Gsk-3, Gbp, Axin, and APC in Xenopus Axis Specification
Glycogen synthase kinase 3 (GSK-3) is a constitutively active kinase that negatively regulates its substrates, one of which is β-catenin, a downstream effector of the Wnt signaling pathway that isExpand
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Move it or lose it: axis specification in Xenopus
A long-standing question in developmental biology is how amphibians establish a dorsoventral axis. The prevailing view has been that cortical rotation is used to move a dorsalizing activity from theExpand
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cAMP-Dependent Protein Kinase Phosphorylations on Tau in Alzheimer’s Disease
To elucidate the role cAMP-dependent protein kinase (PKA) phosphorylations on tau play in Alzheimer’s disease, we have generated highly specific monoclonal antibodies, CP-3 and PG-5, which recognizeExpand
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Neurosecretory control of aging in Caenorhabditis elegans.
In the nematode Caenorhabditis elegans, an insulin receptor signaling pathway regulates adult life span and developmental arrest at the dauer larval stage. Here we show that the unc-64 and unc-31Expand
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GBP binds kinesin light chain and translocates during cortical rotation in Xenopus eggs
In Xenopus, axis development is initiated by dorsally elevated levels of cytoplasmic β-catenin, an intracellular factor regulated by GSK3 kinase activity. Upon fertilization, factors that increaseExpand
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Characterization of a Nonparasitic Isolate of Bursaphelenchus xylophilus.
Bursaphelenchus xylophilus isolate MPSy-1av was subcultured from pathotype MPSy-1. MPSy-1av is nonparasitic and does not establish in Pinus sylvestris, P. strobus, P. nigra, or P. taeda. This isolateExpand
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Automatic Eukaryotic Artificial Chromosomes: Possible Creation of Bacterial Organelles in Yeast
Publisher Summary This chapter discusses the automatic eukaryotic artificial chromosomes (AEAC). Evolutionary theory proposes that mitochondria, plastids, and chloroplasts originated by theExpand
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