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The in vivo neuromodulatory effects of the herbal medicine ginkgo biloba
It is revealed that diets supplemented with Ginkgo biloba extract have notable neuromodulatory effects in vivo and illustrates the utility of genome-wide expression monitoring to investigate the biological actions of complex extracts. Expand
Requirement of Monooxygenase-Mediated Steps for Sterigmatocystin Biosynthesis by Aspergillus nidulans
It is shown that strains disrupted atstcF, encoding a P-450 monooxygenase similar to A. parasiticus avnA, accumulate averantin as determined by radiolabeled feeding and extraction studies. Expand
Initial characterization of a type I fatty acid synthase and polyketide synthase multienzyme complex NorS in the biosynthesis of aflatoxin B(1).
The N-acetylcysteamine thioester of hexanoic acid can substitute for the catalytic functions of HexA/B to initiate norsolorinic acid synthesis by the complex in the presence of only malonylCoA. Expand
Age-related effects of Ginkgo biloba extract on synaptic plasticity and excitability
The rapid effects of EGb 761 on plasticity indicate a direct interaction with the glutamatergic system and raise interesting implications with respect to a mechanism explaining its effect on cognitive enhancement in human subjects experiencing dementia. Expand
Demonstration of the catalytic roles and evidence for the physical association of type I fatty acid synthases and a polyketide synthase in the biosynthesis of aflatoxin B1.
The impaired ability of Dis-1 and Dis-2, harboring modified Fas-1 enzymes, to carry out norsolorinic acid synthesis implies the need for FAS-1 (and possibly also FAs-2) to physically associate with the PKS before biosynthesis can begin. Expand
Pyocyanin isolated from a marine microbial population: synergistic production between two distinct bacterial species and mode of action.
Experiments designed to probe the synergistic role of the microorganisms are presented and full characterization of the blue natural product, pyocyanin, is provided, showing the overall potential of the method to reveal the primary biological/cellular effects of a natural product. Expand
Elucidating the molecular mechanism of cardiac remodeling using a comparative genomic approach.
It is shown that regional differences in gene expression exist in the heart and common pathways that are coregulated in both models exist, and these might be central to the hypertrophic phenotype regardless of the initial hypertrophic stimuli. Expand
Effect of Ginkgo biloba (EGb 761) on differential gene expression.
Genome-wide expression monitoring with high-density oligonucleotide arrays provides one way to examine the molecular targets of plant extracts and may prove a useful tool in evaluating their therapeutic claims. Expand
Proline Promoted Synthesis of Ring-Fused Homodimers: Self-Condensation of α,β-Unsaturated Aldehydes†
1,2,4-Trisubstituted cyclohexadienals can be prepared synthetically by self-condensation of β-methyl substituted α,β-unsaturated aldehydes. While molecules with this structural scaffold have beenExpand
In vitro biosynthesis of the antitumor agent azinomycin B.
The first demonstration of a protein cell-free system capable of supporting complete in vitro biosynthesis of the antitumor agent azinomycin B is provided. Expand