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Cyanobacterial toxins, exposure routes and human health
- G. Codd, S. Bell, K. Kaya, C. Ward, K. Beattie, J. Metcalf
- Environmental Science, Biology
- 1 October 1999
Advances in the recognition of cyanobacterial toxins and their toxicity, and of the exposure routes with reference to human health, namely via skin contact, inhalation, haemodialysis and ...
Comparative toxicity of four microcystins of different hydrophobicities to the protozoan, Tetrahymena pyriformis
Positive correlations between all toxicological endpoints and log P occurred, with the most hydrophobic toxin, MC‐LF, being 1·4 to 3·5 times more toxic than MC‐LR.
IN SILICO PREDICTION OF DRUG BINDING TO CYP2D6: IDENTIFICATION OF A NEW METABOLITE OF METOCLOPRAMIDE
It is suggested that those experiencing adverse reactions with metoclopramide, e.g., extrapyramidal syndrome, are likely to have a particular CYP2D6 genotype/phenotype, and warrants further investigation.
Directional trans-epithelial transport of organic anions in porcine LLC-PK1 cells that co-express human OATP1B1 (OATP-C) and MRP2.
Colorimetric protein phosphatase inhibition assay of laboratory strains and natural blooms of cyanobacteria: comparisons with high-performance liquid chromatographic analysis for microcystins.
A rapid, simple and sensitive colorimetric protein phosphatase 1 inhibition assay, utilising the activity of protein phosph atase 1 as expressed in a recombinant strain of Escherichia coli, towards the chromogenic substrate, p-nitrophenyl phosphate, is optimised.
Why Is Quinidine an Inhibitor of Cytochrome P450 2D6?
Homology modeling and molecular docking were used to predict the modes of quinidine binding to the wild-type and mutant enzymes; these were able to rationalize the experimental observations.
Effects of salinity and two coastal waters on the growth and toxin content of the dinoflagellate Alexandrium minutum
- D. Grzebyk, C. Béchemin, C. Ward, Celine Vérité, G. Codd, S. Maestrini
- Environmental Science
- 1 October 2003
The dinoflagellate Alexandrium minutum strain AM89BM was studied to investigate its capacity to adapt to different salinities and the influence of salinity on cellular content of paralytic shellfish toxins (PST), in batch culture in enriched offshore seawater media and hypothesize that toxin biosynthesis was greatly weakened due to the lack of amino acid precursors in prey material.
Cyanobacterial toxins: occurrence, modes of action, health effects and exposure routes.
The findings and events indicate an incomplete understanding of the exposure routes of these natural toxins and the need for greater awareness of their occurrence and properties among users of waterbodies which are prone to cyanobacterial bloom development.
The 2000 Canine Distemper Epidemic in Caspian Seals (Phoca caspica): Pathology and Analysis of Contributory Factors
The primary diagnosis in 11 of 13 seals was canine distemper, characterized by broncho-interstitial pneumonia, lymphocytic necrosis and depletion in lymphoid organs, and the presence of typical intracytoplasmic inclusion bodies in multiple epithelia, which were comparable to those of Caspian seals in previous years.
Widening Perceptions of The Occurrence And Significance of Cyanobacterial Toxins
Understanding of the health hazards presented by CTX is gradually being advanced from several sources, including fundamental studies of the toxicology of purified CTX, ranging from molecular in vitro studies to toxicity trials with animals and investigations, albeit limited, of animal poisonings and human health problems associated with—or attributed to—CTX.