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Epidermal growth factor receptor: mechanisms of activation and signalling.
The epidermal growth factor (EGF) receptor (EGFR) is one of four homologous transmembrane proteins that mediate the actions of a family of growth factors including EGF, transforming growthExpand
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An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors.
Recent crystallographic studies have provided significant new insight into how receptor tyrosine kinases from the EGF receptor or ErbB family are regulated by their growth factor ligands. EGFExpand
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Crystal Structure of a Truncated Epidermal Growth Factor Receptor Extracellular Domain Bound to Transforming Growth Factor α
We report the crystal structure, at 2.5 A resolution, of a truncated human EGFR ectodomain bound to TGFalpha. TGFalpha interacts with both L1 and L2 domains of EGFR, making many main chain contactsExpand
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The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors.
ErbB2 does not bind ligand, yet appears to be the major signaling partner for other ErbB receptors by forming heteromeric complexes with ErbB1, ErbB3, or ErbB4. The crystal structure of residuesExpand
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Structure and function of the type 1 insulin-like growth factor receptor
Abstract. The type 1 insulin-like growth factor receptor (IGF-1R), a transmembrane tyrosine kinase, is widely expressed across many cell types in foetal and postnatal tissues. Activation of theExpand
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Structure of the insulin receptor ectodomain reveals a folded-over conformation
The insulin receptor is a phylogenetically ancient tyrosine kinase receptor found in organisms as primitive as cnidarians and insects. In higher organisms it is essential for glucose homeostasis,Expand
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Structure of potyvirus coat proteins and its application in the taxonomy of the potyvirus group.
Publisher Summary The potyvirus group is the largest and economically most important of the 28 plant virus groups and families currently recognized. It contains 152 definitive and possible membersExpand
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The N and C termini of the coat proteins of potyviruses are surface-located and the N terminus contains the major virus-specific epitopes.
Summary Mild proteolysis by trypsin of particles of six potyviruses (bean yellow mosaic virus, clover yellow vein virus, Johnson grass mosaic virus, passion-fruit woodiness virus, potato virus Y andExpand
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How insulin engages its primary binding site on the insulin receptor
Insulin receptor signalling has a central role in mammalian biology, regulating cellular metabolism, growth, division, differentiation and survival. Insulin resistance contributes to the pathogenesisExpand
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Characterization of Munc-18c and Syntaxin-4 in 3T3-L1 Adipocytes
We have previously identified three mammalian Sec1/Munc-18 homologues in adipocytes (Tellam, J. T., McIntosh, S., and James, D. E. (1995) J. Biol. Chem. 270, 5857-5863). These proteins are thought toExpand
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