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TAK1 is a ubiquitin-dependent kinase of MKK and IKK
TRAF6 is a signal transducer that activates IκB kinase (IKK) and Jun amino-terminal kinase (JNK) in response to pro-inflammatory mediators such as interleukin-1 (IL-1) and lipopolysaccharides (LPS).Expand
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Positive Regulation of Interferon Regulatory Factor 3 Activation by Herc5 via ISG15 Modification
ABSTRACT Virus infection induces host antiviral responses, including induction of type I interferons. Transcription factor interferon regulatory factor 3 (IRF3) plays a pivotal role and is tightlyExpand
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Cutting Edge: TNF-Induced MicroRNAs Regulate TNF-Induced Expression of E-Selectin and Intercellular Adhesion Molecule-1 on Human Endothelial Cells: Feedback Control of Inflammation
MicroRNAs (miRNAs) pair with target sequences in the 3′ untranslated region of mRNAs to posttranscriptionally repress gene expression. In this study, we report that TNF-mediated induction ofExpand
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TRIM21 Is Essential to Sustain IFN Regulatory Factor 3 Activation during Antiviral Response1
Virus infection induces host antiviral responses including induction of type I IFNs. Transcription factor IFN regulatory factor 3 (IRF3) plays an essential role and is tightly regulated in thisExpand
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IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (H1N1) Virus
The 2009 flu pandemic involved the emergence of a new strain of a swine-origin H1N1 influenza virus (S-OIV H1N1) that infected almost every country in the world. Most infections resulted inExpand
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IFN-Induced TPR Protein IFIT3 Potentiates Antiviral Signaling by Bridging MAVS and TBK1
Intracellular RNA viruses are sensed by receptors retinoic acid-inducible gene I/MDA5, which trigger formation of the mitochondrial antiviral signaling (MAVS) complex on mitochondria. Consequently,Expand
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Herc5 Attenuates Influenza A Virus by Catalyzing ISGylation of Viral NS1 Protein
Ubiquitin-like protein ISG15, which is robustly induced by IFN or virus, is implicated to inhibit influenza A virus (IAV) in vivo. But the underlying mechanism still remains largely unknown. In thisExpand
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Negative Regulation of TLR Inflammatory Signaling by the SUMO-deconjugating Enzyme SENP6
The signaling of Toll-like receptors (TLRs) induces host defense against microbial invasion. Protein posttranslational modifications dynamically shape the strength and duration of the signalingExpand
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Tom70 mediates activation of interferon regulatory factor 3 on mitochondria
Intracellular RNA viruses are sensed by receptors retinoic acid-inducible gene 1 (RIG-I)/melanoma differentiation-associated gene 5 (MDA5) that trigger the formation of MAVS signal complex onExpand
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AU-Rich-Element-Dependent Translation Repression Requires the Cooperation of Tristetraprolin and RCK/P54
ABSTRACT AU-rich elements (AREs), residing in the 3′ untranslated region (UTR) of many labile mRNAs, are important cis-acting elements that modulate the stability of these mRNAs by collaborating withExpand
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