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Ara-C and anti-CD47 antibody combination therapy eliminates acute monocytic leukemia THP-1 cells in vivo and in vitro.
It is suggested that CD47 is an antibody target in LSCs and combination treatment with cytarabine and anti-CD47 monoclonal antibody represents an attractive option for the therapeutic targeting of acute monocytic leukemia. Expand
Structure of the rat gonadotropin releasing hormone (rGnRH) gene promoter and functional analysis in hypothalamic cells.
It is concluded that different portions of the 5'-flanking region, which are activating and suppressing in nature, are critical for hypothalamic expression of the rGnRH gene. Expand
Effect of high-level natural radiation on chromosomes of residents in southern China
An increase of the frequency of dicentrics and rings in HBRA, where the natural radiation level is three to five times higher than in the control area, was within the range of individual variation in the controls. Expand
Updated efficacy and quality-of-life (QoL) analyses in OPTIMAL, a phase III, randomized, open-label study of first-line erlotinib versus gemcitabine/carboplatin in patients with EGFR-activating
  • C. Zhou, Y. Wu, +9 authors L. Zhang
  • Medicine
  • Journal of clinical oncology : official journal…
  • 20 May 2011
E improved PFS compared with G/C as first-line treatment for EGFR Act Mut+ NSCLC, and patients' QoL was also significantly improved with E vs G /C. Expand
Intraoperative mechanical ventilation strategies for obese patients: a systematic review and network meta‐analysis
  • C. Wang, N. Zhao, +7 authors E. Li
  • Medicine
  • Obesity reviews : an official journal of the…
  • 1 June 2015
Volume‐controlled ventilation with higher PEEP plus single recruitment manoeuvres (VCV + higher PEEP  + single RM) was associated with the highest PaO2/FiO2 ratio, improving intraoperative pulmonary compliance and reducing the incidence of intraoperative atelectasis. Expand
Molecular cloning and sequencing of the cDNA of cop1 gene from Pisum sativum.
Investigation of the cDNA of cop1 gene from pea showed that Cop1 protein was present in seedlings germinated both in light and darkness and Sequence comparison between Cop1 proteins of pea and Arabidopsis thaliana revealed that the twoCop1 proteins were highly homologous in the regions with functional domains and at the C-terminus. Expand
Significance of MNK1 in prognostic prediction and chemotherapy development of epithelial ovarian cancer
In vitro study demonstrated that MNK1 can promote cell proliferation through regulating the phosphorylation level of eukaryotic initiation factor 4E and can act as a potential target for novel chemotherapy development towards EOC. Expand
Association analysis between HFM1 variation and primary ovarian insufficiency in Chinese women
The data suggested that HFM1 gene might be associated with primary ovarian insufficiency in Chinese population. Expand
The efficacy and safety of intensified enteric‐coated mycophenolate sodium with low exposure of calcineurin inhibitors in Chinese de novo kidney transplant recipients: a prospective study
This study investigated the efficacy and safety of a transient intensified enteric‐coated mycophenolate sodium dosing regimen with low exposure of calcineurin inhibitors in Chinese de novo kidney transplantation. Expand
Identification of a novel frame-shift mutation in PRSS1 gene in Han patients with autoimmune pancreatitis.
  • F. Gao, Y. Li, +5 authors Z. Xu
  • Biology, Medicine
  • Current molecular medicine
  • 28 February 2014
PRSS1: IVS 2 +56_60 del CCCAG is a noval mutant which may contribute to AIP pathogenesis and is reported to be a deletion mutation at exon 2 of PRSS1 gene which encoded a truncated PR SS1 protein without trypsinogen activation peptide (TAP). Expand