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Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition
The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development.
It is suggested that activation of the HIF alpha pathway in developing bone increases bone modeling events through cell-nonautonomous mechanisms to coordinate the timing, direction, and degree of new blood vessel formation in bone.
Activation of the hypoxia-inducible factor-1α pathway accelerates bone regeneration
- C. Wan, S. Gilbert, T. Clemens
- Biology, MedicineProceedings of the National Academy of Sciences
- 15 January 2008
The HIF-1α pathway is identified as a critical mediator of neoangiogenesis required for skeletal regeneration and the application of HIF activators as therapies to improve bone healing is suggested.
TGF-β1-induced Migration of Bone Mesenchymal Stem Cells Couples Bone Resorption and Formation
It is shown using in vitro and in vivo models that active TGF-β1 released during bone resorption coordinates bone formation by inducing migration of bone marrow stromal cells, also known as bone mesenchymal stem cells, to theBone resorptive sites and that this process is mediated through a SMAD signaling pathway.
Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression.
Prolyl hydroxylase inhibitors increase neoangiogenesis and callus formation following femur fracture in mice
It is suggested that HIF activation is a viable approach to increase vascularity and bone formation following skeletal trauma and in a stabilized fracture model in vivo.
Bioreactor Expansion of Human Adult Bone Marrow‐Derived Mesenchymal Stem Cells
It is concluded that the rotary bioreactor with the modified Myelocult medium reported in this study may be used to rapidly expand MSCs.
Allogenic peripheral blood derived mesenchymal stem cells (MSCs) enhance bone regeneration in rabbit ulna critical‐sized bone defect model
It is demonstrated that the rabbitPBMSCs possessed multidifferentiation potential comparable with BMMSCs, and allogenic PBMSCs seeded onto porous calcium phosphate resorbable substitutes enhanced bone regeneration in the rabbit ulna critical‐sized bone defect model, suggesting allogenic MBMSCs may be a new source of circulating osteogenic stem cells for bone regeneration and tissue engineering.
Flavonoid Compound Icariin Activates Hypoxia Inducible Factor-1α in Chondrocytes and Promotes Articular Cartilage Repair
The results suggest that Icariin may inhibit PHD activity likely through competition for cellular iron ions and therefore it may serve as an HIF-1α activator to promote articular cartilage repair through regulating chondrocyte functions.
Concise Review: Multipotent Mesenchymal Stromal Cells in Blood
In this review, current studies/knowledge about peripheral blood‐derived multipotent mesenchymal stromal cells is summarized, and the above‐mentioned topics are discussed.