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Regulation of Cerebral Cortical Size by Control of Cell Cycle Exit in Neural Precursors
Transgenic mice expressing a stabilized β-catenin in neural precursors develop enlarged brains with increased cerebral cortical surface area and folds resembling sulci and gyri of higher mammals.Expand
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Expression of Cux‐1 and Cux‐2 in the subventricular zone and upper layers II–IV of the cerebral cortex
Little is known about how neurons in the different layers of the mammalian cerebral cortex are specified at the molecular level. Expression of two homologues of the Drosophila homeobox Cut gene,Expand
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Doublecortin Is a Microtubule-Associated Protein and Is Expressed Widely by Migrating Neurons
Doublecortin (DCX) is required for normal migration of neurons into the cerebral cortex, since mutations in the human gene cause a disruption of cortical neuronal migration. To date, little is knownExpand
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Characterization of Foxp2 and Foxp1 mRNA and protein in the developing and mature brain
Foxp2 and Foxp1 are recently identified members of the Fox family of winged‐helix/forkhead transcription factor genes. A recent study has found that mutations in human FOXP2 produce a severe languageExpand
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Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci
Analysis of de novo CNVs (dnCNVs) from the full Simons Simplex Collection (SSC) (N = 2,591 families) replicates prior findings of strong association with autism spectrum disorders (ASDs) and confirmsExpand
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Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1α/CXC chemokine receptor 4 pathway
Migration toward pathology is the first critical step in stem cell engagement during regeneration. Neural stem cells (NSCs) migrate through the parenchyma along nonstereotypical routes in a preciseExpand
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Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared geneticExpand
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Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism
We have undertaken a genome-wide analysis of rare copy-number variation (CNV) in 1124 autism spectrum disorder (ASD) families, each comprised of a single proband, unaffected parents, and, in mostExpand
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Identifying Autism Loci and Genes by Tracing Recent Shared Ancestry
To find inherited causes of autism-spectrum disorders, we studied families in which parents share ancestors, enhancing the role of inherited factors. We mapped several loci, some containing large,Expand
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The Cerebrospinal Fluid Provides a Proliferative Niche for Neural Progenitor Cells
Cortical development depends on the active integration of cell-autonomous and extrinsic cues, but the coordination of these processes is poorly understood. Here, we show that the apical complexExpand
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