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Aspartate β‐hydroxylase modulates cellular senescence through glycogen synthase kinase 3β in hepatocellular carcinoma
TLDR
A new mechanism that promotes HCC growth and progression by modulating senescence of tumor cells is identified and suggest that ASPH enzymatic activity is a novel therapeutic target for HCC. Expand
Antiviral activity of metal chelates of caffeic acid and similar compounds towards herpes simplex, VSV‐Ebola pseudotyped and vaccinia viruses
TLDR
Since the caffeic acid chelates target an extra‐cellular process, they might be able to be combined with existing medications that target an intracellular process to achieve greater viral control. Expand
Extraction, Purification, and Spectroscopic Characterization of a Mixture of Capsaicinoids
This laboratory experiment provides a safe and effective way to instruct undergraduate organic chemistry students about natural-product extraction, purification, and NMR spectroscopicExpand
Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic
TLDR
Analysis of 11 novel compounds revealed the discovery of three analogues that best induce RXR-mediated transcriptional activity, stimulate apoptosis, have comparable K(i) and EC(50) values to 1, and are selective RXR agonists. Expand
Analysis of differential secondary effects of novel rexinoids: select rexinoid X receptor ligands demonstrate differentiated side effect profiles
TLDR
It is shown here for the first time that potent rexinoid activity can be uncoupled from drastic lipid changes and thyroid axis variations, and it is proposed that rex inoids can be developed with improved side effect profiles than the parent compound, bexarotene. Expand
Synthesis of 2, 5-Dichloro-2, 5-dimethylhexane by an SN1 reaction
This laboratory experiment was developed to provide a safe, economical, and effective way to instruct undergraduate organic chemistry students about the unimolecular nucleophilic substitution (SN1)Expand
Retinoid X Receptor Selective Agonists and their Synthetic Methods.
TLDR
Over the last 25 years there have been several reports on the design and synthesis of small molecule rexinoids, and this review summarizes the synthetic methods for several of the most potent rex inoids thus far reported. Expand
Modeling, synthesis, and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic
TLDR
Seven modeled novel compounds described and evaluated for their retinoid X receptor (RXR) selective agonism demonstrate selectivity for RXR and minimal crossover onto the RAR compared to all-trans-retinoic acid, with select analogues also reducing inhibition of other RXR-dependent pathways. Expand
Modeling, Synthesis and Biological Evaluation of Potential Retinoid X Receptor‐Selective Agonists: Novel Halogenated Analogues of
TLDR
In an array of eight novel compounds, four analogues were discovered to promote RXR‐mediated transcription with EC50 values similar to that of 1 and are selective RXR agonists. Expand
Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR)-Selective Agonists: Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid
TLDR
The results suggest that modifications of potent RXR agonists such as NEt-TMN can lead to improved biological selectivity and potency compared with the known therapeutic. Expand
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