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Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells
The anti-cancer effects of metformin, the most widely used drug for type 2 diabetes, alone or in combination with ionizing radiation were studied with MCF-7 human breast cancer cells and FSaII mouse fibrosarcoma cells, finding it was preferentially cytotoxic to cancer stem cells relative to non-cancer stem cells. Expand
Implication of Blood Flow in Hyperthermic Treatment of Tumors
Tumor blood flow appears to be implicated in such a heat-induced increase in the intratumor acidity, and thereby a greater temperature rise in tumors may occur, resulting in greater damage in tumor relative to normal tissues. Expand
Simultaneous inhibition of the receptor kinase activity of vascular endothelial, fibroblast, and platelet-derived growth factors suppresses tumor growth and enhances tumor radiation response.
It is concluded that SU6668 is a potent therapeutic agent potentially useful to suppress tumor growth and enhance the response of tumors to radiotherapy. Expand
Enhancement of tumor thermal therapy using gold nanoparticle–assisted tumor necrosis factor-α delivery
A newly developed nanoparticle delivery system consisting of 33-nm polyethylene glycol–coated colloidal gold nanoparticles (PT-cAu-TNF-α) with incorporated T NF-α payload (several hundred TNF- α molecules per nanoparticle) is used to maximize tumor damage and minimize systemic exposure to TNF -α. Expand
Influence of Tumor pH on Therapeutic Response
The intratumor microenvironment is intrinsically acidic due mainly to accumulation of lactic acid as a result of increased aerobic and anaerobic glycolysis by the tumor cells. In general, theExpand
Mechanism of action of lonidamine in the 9L brain tumor model involves inhibition of lactate efflux and intracellular acidification
In vitro measurements of cultured 9L tumor cell intra- and extracellular lactate, pentose phosphate pathway (PPP) and hexokinase (HK) activities suggest that the mode of action of LND involves inhibition of lactate efflux and intracellular acidification, which may be exploitable for sensitizing gliomas to radiation, chemotherapy or hyperthermia. Expand
Radiobiological basis of SBRT and SRS
Indications are that the extensive tumor cell death due to the direct effect of radiation on tumor cells and the secondary effect through vascular damage may lead to massive release of tumor-associated antigens and various pro-inflammatory cytokines, thereby triggering an anti-tumor immune response. Expand
Improvement of Tumor Oxygenation by Mild Hyperthermia
The potential usefulness of mild hyperthermia to enhance the response of human tumors to radiotherapy by improving tumor oxygenation merits continued investigation. Expand
Anginex synergizes with radiation therapy to inhibit tumor growth by radiosensitizing endothelial cells
Investigation of the effect of anginex on established tumor vasculature as an adjuvant to radiation therapy of solid tumors supports the idea that the combination of the antiangiogenic agentAnginex and radiation may lead to improved clinical outcome in treating cancer patients. Expand
Upregulation of NAD(P)H:quinone oxidoreductase by radiation potentiates the effect of bioreductive beta-lapachone on cancer cells.
It is shown that combined radiotherapy and beta-lap treatment can have a significant effect on human tumor xenografts, and the growth of A549 tumors induced in immunocompromised mice could be markedly suppressed by local radiation therapy when followed by beta- Lap treatment. Expand