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Preliminary findings for two new measures of social and role functioning in the prodromal phase of schizophrenia.
INTRODUCTION Research on prediction and prevention of schizophrenia has increasingly focused on prodromal (prepsychosis) social and role dysfunction as developmentally early, stable, andExpand
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The schizophrenia prodrome revisited: a neurodevelopmental perspective.
Despite the widespread acceptance of the neurodevelopmental model of schizophrenia, its application to research concerned with the prodromal phase of illness is limited. Little recognition has beenExpand
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Generalized and Specific Neurocognitive Deficits in Prodromal Schizophrenia
BACKGROUND Neurocognitive deficits are considered to be central to the pathophysiology of schizophrenia, and the neurodevelopmental model suggests that such deficits precede full-blown psychosis. TheExpand
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Differentiation in the preonset phases of schizophrenia and mood disorders: evidence in support of a bipolar mania prodrome.
OBJECTIVE The presence and specificity of a bipolar prodrome remains questioned. We aimed to characterize the prodrome prior to a first psychotic and nonpsychotic mania and to examine the phenotypicExpand
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Nonspecific and attenuated negative symptoms in patients at clinical high-risk for schizophrenia
BACKGROUND Retrospective studies have shown that nonspecific psychopathology and negative symptoms, including social isolation and academic dysfunction, tend to precede onset of psychosis. TheExpand
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Can antidepressants be used to treat the schizophrenia prodrome? Results of a prospective, naturalistic treatment study of adolescents.
OBJECTIVE This study reports the results of a prospective, naturalistic treatment study of adolescents considered to be in the prodromal (i.e., prepsychotic) phase of schizophrenia. METHODExpand
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Early identification and high-risk strategies for bipolar disorder.
OBJECTIVES To describe and compare the relative merits of different identification strategies for individuals at risk for bipolar disorder (BPD). METHODS Selective review of data that support earlyExpand
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Neuropsychological functioning in adolescents and young adults at genetic risk for schizophrenia and affective psychoses: results from the Harvard and Hillside Adolescent High Risk Studies.
Siblings and offspring of persons with schizophrenia carry elevated genetic risk for the illness and manifest attentional and memory impairments. Because less is known about other neuropsychologicalExpand
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Spatial working memory deficits in adolescents at clinical high risk for schizophrenia
Identifying endophenotypic markers is crucial to schizophrenia research for finding appropriate preventive strategies. Working memory (WM) deficit has been suggested as a marker for schizophrenia butExpand
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The assessment of "prodromal schizophrenia": unresolved issues and future directions.
Because of the novelty of research with clinical high risk ("prodromal") patients, many unresolved issues exist concerning how the prodromal state is defined and measured. Data are presented from theExpand
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