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A protein deacetylase SIRT1 is a negative regulator of metalloproteinase‐9
Inappropriate elevation of matrix metalloproteinase‐9 (MMP9) is reported to be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). The object of this study was to identifyExpand
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Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma.
Neutrophilic inflammation in acute exacerbations of asthma tends to be resistant to treatment with glucocorticoids. This may be related to decreased activity and expression of histone deacetylase-2Expand
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Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2.
Histone deacetylases (HDACs) are key molecules involved in epigenetic regulation of gene expression. We have previously demonstrated that oxidative stress caused a reduction in HDAC2, resulting inExpand
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Oxidative stress dependent microRNA-34a activation via PI3Kα reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells
Sirtuin-1 (SIRT1) and SIRT6, NAD+-dependent Class III protein deacetylases, are putative anti-aging enzymes, down-regulated in patients with chronic obstructive pulmonary disease (COPD), which isExpand
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