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Sp1 transcription factor: A long-standing target in cancer chemotherapy.
The acknowledgment that several of those compounds are safe enough might accelerate their introduction into clinical usage in patients with tumors that over-express Sp1, as well as promoting the degradation of Sp protein factors. Expand
Conserved high activity binding peptides are involved in adhesion of two detergent-resistant membrane-associated merozoite proteins to red blood cells during invasion.
- A. Z. Obando-Martinez, H. Curtidor, +4 authors M. Patarroyo
- Chemistry, Medicine
- Journal of medicinal chemistry
- 27 May 2010
Detergent resistant membranes (DRMs) of Plasmodium falciparum merozoites contain a large number of glycosylphosphatidylinositol (GPI)-anchored proteins that have been implicated in interactions… Expand
Molecular modeling and in silico characterization of Mycobacterium tuberculosis TlyA: Possible misannotation of this tubercle bacilli-hemolysin
- Nelson E. Arenas, L. Salazar, +4 authors A. Gómez
- Biology, Medicine
- BMC Structural Biology
- 28 March 2011
The manual in silico curation suggested that TlyA is involved in ribosomal biogenesis and that there is a functional annotation error regarding this protein family in several microbial and plant genomes, including the M. tuberculosis genome. Expand
Computational Prediction and Experimental Assessment of Secreted/Surface Proteins from Mycobacterium tuberculosis H37Rv
- C. Vizcaíno, Daniel Restrepo-Montoya, +7 authors M. Patarroyo
- Biology, Computer Science
- PLoS Comput. Biol.
- 1 June 2010
The genome of Mycobacterium tuberculosis H37Rv was screened using Machine Learning tools that included feature-based predictors, general localizers and transmembrane topology predictors to identify proteins that are potentially secreted to the surface of M. tuberculosis or to the extracellular milieu through different secretory pathways. Expand
Conserved high activity binding peptides from the Plasmodium falciparum Pf34 rhoptry protein inhibit merozoites in vitro invasion of red blood cells
- Gabriela Arévalo-Pinzón, H. Curtidor, M. Vanegas, C. Vizcaíno, M. Patarroyo, M. Patarroyo
- Medicine, Biology
- 1 November 2010
In vitro assays showed that Pf34 high activity binding peptides (HABPs) inhibit invasion of RBCs by P. falciparum merozoites,Therefore, Pf34 could act as an adhesin during invasion and supporting the inclusion of Pf34 HABPs in further studies to develop antimalarial control methods. Expand
Synthetic peptides from conserved regions of the Plasmodium falciparum early transcribed membrane and ring exported proteins bind specifically to red blood cell proteins.
The results suggest that the REX and E-TRAMP families participate in relevant interactions with RBC membrane proteins, which highlight these proteins as potential targets for the development of fully effective immunoprophylactic methods. Expand
The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcription.
- A. Fernández-Guizán, Sylvia Mansilla, +5 authors J. Portugal
- Biology, Medicine
- Chemico-biological interactions
- 5 August 2014
Evidence is presented that the binding of DIG-MSK to DNA shares the general features of other mithramycins such as the preference for C/G-rich tracts, but there are some differences in the strength of binding and the DNA sequence preferentially recognized by DIG -MSK. Expand
In Vitro and In Vivo Studies for Assessing the Immune Response and Protection-Inducing Ability Conferred by Fasciola hepatica-Derived Synthetic Peptides Containing B- and T-Cell Epitopes
The bioinformatics approach used in the present study led to the identification of seven peptides as vaccine candidates against the infection caused by Fasciola hepatica (a liver-fluke trematode), however, vaccine efficacy must be evaluated in other host species, including those having veterinary importance. Expand
Characterization of Plasmodium falciparum integral membrane protein Pf25‐IMP and identification of its red blood cell binding sequences inhibiting merozoite invasion in vitro
- H. Curtidor, Gabriela Arévalo, +4 authors M. Patarroyo
- Biology, Medicine
- Protein science : a publication of the Protein…
- 1 September 2008
The data suggest a possible role of Pf25‐IMP in merozoite invasion to RBCs and support its inclusion in further immunological studies for evaluating its potential as vaccine candidates. Expand
Genome-Wide Modulation of Gene Transcription in Ovarian Carcinoma Cells by a New Mithramycin Analogue
Ovarian cancer has a poor prognosis due to intrinsic or acquired resistance to some cytotoxic drugs, raising the interest in new DNA-binding agents such as mithramycin analogues as potential… Expand