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The Associations of Fibroblast Growth Factor 23 and Uncarboxylated Matrix Gla Protein With Mortality in Coronary Artery Disease: The Heart and Soul Study
TLDR
In outpatients with stable CAD, higher FGF23 and lower ucMGP levels are independently associated with mortality and CVD events.
Differential Expression of Bone Matrix Regulatory Proteins in Human Atherosclerotic Plaques
TLDR
The observed expression patterns suggest a tight regulation of the expression of bone matrix regulatory proteins during human atherogenesis, which might suggest a regulatory role of these proteins not only in osteoclastogenesis but also in atherosclerotic calcification.
The role of menaquinones (vitamin K₂) in human health.
TLDR
It is concluded that further investigations are needed to establish how differences among the vitamin K forms may influence tissue specificities and their role in human health, and there is merit for considering both menaquinones and phylloquinone when developing future recommendations for vitamin K intake.
Effect of vitamin K2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trial.
TLDR
This is the first study showing that inactive MGP levels can be decreased markedly by daily vitamin K(2) supplementation, and provides the rationale for intervention trials aimed at decreasing vascular calcification in hemodialysis patients by vitamin K supplementation.
Determination of phylloquinone and menaquinones in food. Effect of food matrix on circulating vitamin K concentrations.
TLDR
It is concluded that the contribution of K(2) vitamins (menaquinones) to the human vitamin K status is presently underestimated, and that their potential interference with oral anticoagulant treatment needs to be investigated.
Nutritional Intake of Vitamins K1 (Phylloquinone) and K2 (Menaquinone) in The Netherlands
TLDR
It is concluded that K1 is the major form of nutritional vitamin K, that total vitamin K intake is higher than in other populations described and that the correlation betweenitamin K intake and serum concentration is poor.
Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7.
TLDR
MK-7 induced more complete carboxylation of osteocalcin, and hematologists should be aware that preparations supplying 50 mug/d or more of MK-7 may interfere with oral anticoagulant treatment in a clinically relevant way.
Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study.
TLDR
It is suggested that an adequate intake of menaquinone could be important for CHD prevention and not related to any of the outcomes.
Circulating nonphosphorylated carboxylated matrix gla protein predicts survival in ESRD.
TLDR
Lower levels of circulating dp-cMGP may serve as a predictor of mortality in dialysis patients, and whether vitamin K supplementation improves outcomes requires further study.
Vitamin K1 Supplementation Retards Bone Loss in Postmenopausal Women Between 50 and 60 Years of Age
TLDR
If co-administered with minerals and vitamin D, vitamin K1 may substantially contribute to reducing postmenopausal bone loss at the site of the femoral neck.
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