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The Associations of Fibroblast Growth Factor 23 and Uncarboxylated Matrix Gla Protein With Mortality in Coronary Artery Disease: The Heart and Soul Study
BACKGROUND Fibroblast growth factor 23 (FGF23), uncarboxylated matrix Gla protein (ucMGP), and fetuin-A are regulators of mineral metabolism and inhibitors of vascular calcification. Whether… Expand
Differential Expression of Bone Matrix Regulatory Proteins in Human Atherosclerotic Plaques
- C. R. Dhore, J. Cleutjens, +7 authors M. Daemen
- Medicine, Biology
- Arteriosclerosis, thrombosis, and vascular…
- 1 December 2001
In the present study, we examined the expression of regulators of bone formation and osteoclastogenesis in human atherosclerosis because accumulating evidence suggests that atherosclerotic… Expand
Nutritional Intake of Vitamins K1 (Phylloquinone) and K2 (Menaquinone) in The Netherlands
Vitamin K plays a key role in the hepatic synthesis of blood clotting factors. Recently, other tissues (bone, vessel wall) were shown to produce vitamin K-dependent proteins not involved in blood… Expand
Determination of phylloquinone and menaquinones in food. Effect of food matrix on circulating vitamin K concentrations.
Fluctuations in international normalized ratio values are often ascribed to dietary changes in vitamin K intake. Here we present a database with vitamin K(1) and K(2) contents of a wide variety of… Expand
Effect of vitamin K2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trial.
- R. Westenfeld, Thilo Krueger, +9 authors L. Schurgers
- American journal of kidney diseases : the…
- 1 February 2012
BACKGROUND Vascular calcification is a predictor of cardiovascular morbidity and mortality. Hemodialysis patients experience severe vascular calcifications. Matrix Gla protein (MGP) is a central… Expand
Circulating nonphosphorylated carboxylated matrix gla protein predicts survival in ESRD.
- G. Schlieper, R. Westenfeld, +10 authors L. Schurgers
- Journal of the American Society of Nephrology…
- 1 February 2011
The mechanisms for vascular calcification and its associated cardiovascular mortality in patients with ESRD are not completely understood. Dialysis patients exhibit profound vitamin K deficiency,… Expand
Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study.
Vitamin K-dependent proteins, including matrix Gla-protein, have been shown to inhibit vascular calcification. Activation of these proteins via carboxylation depends on the availability of vitamin K.… Expand
Vitamin K1 Supplementation Retards Bone Loss in Postmenopausal Women Between 50 and 60 Years of Age
Although several observational studies have demonstrated an association between vitamin K status and bone mineral density (BMD) in postmenopausal women, no placebo-controlled intervention trials of… Expand
The role of menaquinones (vitamin K₂) in human health.
- J. W. Beulens, S. Booth, E. G. V. D. van den Heuvel, E. Stoecklin, A. Baka, C. Vermeer
- Biology, Medicine
- The British journal of nutrition
- 28 October 2013
Recent reports have attributed the potential health benefits of vitamin K beyond its function to activate hepatic coagulation factors. Moreover, several studies have suggested that menaquinones, also… Expand
Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7.
- L. Schurgers, K. J. Teunissen, K. Hamulýak, M. J. Knapen, H. Vik, C. Vermeer
- 15 April 2007
Vitamin K is a cofactor in the production of blood coagulation factors (in the liver), osteocalcin (in bone), and matrix Gla protein (cartilage and vessel wall). Accumulating evidence suggests that… Expand