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Animal mitochondrial biogenesis and function: a regulatory cross-talk between two genomes.
Mitochondria play a pivotal role in cell physiology, producing the cellular energy and other essential metabolites as well as controlling apoptosis by integrating numerous death signals. TheExpand
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Physiology of mutants with reduced expression of plasma membrane H+‐ATPase
Two mutations containing insertions and deletions in the promoter in the plasma membrane H+‐ATPase gene (PMA1) of Saccharomyces cerevisiae have been introduced into the genome by homologousExpand
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Drosophila cathepsin B-like proteinase: a suggested role in yolk degradation.
A cysteine, cathepsin B-like proteinase activity has been found in Drosophila embryos. It appears associated with yolk granules and its activity during embryogenesis correlates well with theExpand
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Enhanced tumorigenicity by mitochondrial DNA mild mutations
To understand how mitochondria are involved in malignant transformation we have generated a collection of transmitochondrial cybrid cell lines on the same nuclear background (143B) but with mutantExpand
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Evidence of tissue-specific, post-transcriptional regulation of NRF-2 expression.
Mitochondrial respiratory function requires the expression of genes both from the mitochondrial and nuclear genomes. Nuclear respiratory factor 2 (NRF-2) is a transcription factor required for theExpand
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The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading
Cancer cells exhibit mitochondrial cholesterol (mt-cholesterol) accumulation, which contributes to cell death resistance by antagonizing mitochondrial outer membrane (MOM) permeabilization.Expand
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Wide occurrence of guanosine 5'-tetraphosphate in commercial preparations of GTP.
Abstract Guanosine 5′-tetraphosphate is present in commercial preparations of GTP in proportions from 1–4.5%, apparently regardless of the type of salt, method of preparation, age of the sample orExpand
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Degradation of yolk in the brine shrimp Artemia. Biochemical and morphological studies on the involvement of the lysosomal system
The degradation of yolk granules during the development of Artemia was studied. The results obtained suggest that lysosomes are involved in the process. In homogenates of embryos and larvae atExpand
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Thyroid hormone increases transcription of GA‐binding protein/nuclear respiratory factor‐2 α‐subunit in rat liver
Thyroid hormone (TH) regulates mitochondrial respiratory rate by activating coordinated transcription in the nucleus and mitochondria. Whereas TH activates transcription of mitochondrial genesExpand
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Expression of mitochondrial genes and of the transcription factors involved in the biogenesis of mitochondria Tfam, NRF-1 and NRF-2, in rat liver, testis and brain.
Mitochondrial function requires genes encoded in both mitochondrial and nuclear genomes. Tfam, the activator of mammalian mitochondrial transcription, is encoded in the nucleus and its expression hasExpand
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