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Blue Rubber Bleb Nevus (BRBN) Syndrome Is Caused by Somatic TEK (TIE2) Mutations.
TLDR
Somatic mutations in TEK, the gene encoding TIE2, were discovered in 15 of 17 individuals with blue rubber bleb nevus syndrome and in five of six individuals with sporadically occurring multifocal venous malformations. Expand
Management of scalp psoriasis: guidelines for corticosteroid use in combination treatment.
TLDR
Long term treatment of psoriasis capitis should, in addition to medical advice, also provide patient support and motivation, and vitamin D3 analogues are a patient friendly, tolerable and effective alternative to corticosteroids. Expand
A therapeutic approach to erythrodermic psoriasis: report of a case and a discussion of therapeutic options.
In this case report a patient with therapeutically recalcitrant erythrodermic psoriasis is presented. After various attempts with several major therapies in this patient, the first substantialExpand
Functional characterisation of a novel class of in-frame insertion variants of KRAS and HRAS
TLDR
Biophysical characterization shows the inability of Guanine Nucleotide Exchange Factors to induce GTP loading and reduced intrinsic and GAP-stimulated GTP hydrolysis, and increased RAS signalling is detected in a cellular model system, suggesting a new class of weakly activating clinically relevant RAS variants. Expand
Effects of calcipotriol and clobetasol-17-propionate on UVB-irradiated human skin: an immunohistochemical study.
TLDR
The present study reconfirms the potent effect of topical corticosteroids on various aspects of UVB-challenged skin as calcipotriol interfered especially with one differentiation pathway (transglutaminase) without modulation of otherUVB-induced changes. Expand
Differences between ulcerated and non-ulcerated hemangiomas, a retrospective study of 465 cases.
TLDR
It is concluded that larger, more superficial hemangiomas in areas more susceptible to trauma and contamination were more likely to ulcerate. Expand
Telangiectasia and gingival hyperplasia as side-effects of amlodipine (Norvasc) in a 3-year-old girl.
TLDR
A patient in whom side-e¡ects of antihypertensive drugs were suspected is described, but since the speci¢c combination of telangiectasia of the cheeks and gingival hyperplasia had not been described previously some delay occurred before it was clear that the calcium antagonist amlodipine was responsible. Expand
The utility of GLUT1 as a diagnostic marker in cutaneous vascular anomalies: A review of literature and recommendations for daily practice.
TLDR
GLUT1 can be used as an additional diagnostic tool in cutaneous vascular lesions and is suggestive of infantile hemangioma in vascular malformations. Expand
Tenascin-C is not a useful marker for disease activity in psoriasis.
TLDR
It is concluded that tenascin-C is not useful as a marker for disease activity in psoriasis because levels in most patients were within the normal range and values did not correlate with disease activity. Expand
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