Platelet-derived growth factor signaling and human cancer.
- Jiuhong Yu, C. Ustach, H. Kim
- Biology, MedicineJournal of biochemistry and molecular biology
- 31 January 2003
Important features of the PDGF isoforms and their cell surface receptor subunits are discussed, with regards to signal transduction, PDGF-isoform specific cellular responses, and involvement in angiogensis, and tumorstromal interactions.
EDS1 in tomato is required for resistance mediated by TIR-class R genes and the receptor-like R gene Ve.
The discovery of enhanced susceptibility in the sun1-1 (Le_eds 1-1) mutant plant, which contrasts to reports in Nicotiana benthamiana using virus-induced gene silencing, provides evidence that the intersection of R gene-mediated pathways with general resistance pathways is conserved in a Solanaceous species.
A Potential Oncogenic Activity of Platelet-Derived Growth Factor D in Prostate Cancer Progression
- C. Ustach, M. E. Taube, H. Kim
- BiologyCancer Research
- 1 March 2004
It is shown that LNCaP cells auto-activate latent PDGF DD into the active PDGF domain, which can induce phosphorylation of the β-PDGF receptor and stimulates L NCaP cell proliferation in an autocrine manner, demonstrating a potential oncogenic activity of PDGFDD in the development and/or progression of prostate cancer.
A novel signaling axis of matriptase/PDGF-D/ß-PDGFR in human prostate cancer.
A novel signaling axis of matriptase/PDGF-D/β-PDGFR in PCa is unveiled, providing new insights into functional interplay between serine protease and growth factor signaling networks.
Membrane Targeting by APPL1 and APPL2: Dynamic Scaffolds that Oligomerize and Bind Phosphoinositides
- H. Chial, Ruping Wu, C. Ustach, L. Mcphail, W. Mobley, Yong Q. Chen
- BiologyTraffic : the International Journal of…
- 22 November 2007
A role for APPL proteins as dynamic scaffolds that modulate RAB5‐associated signaling endosomal membranes by their ability to undergo domain‐mediated oligomerization, membrane targeting and phosphoinositide binding is suggested.
Platelet-Derived Growth Factor D Is Activated by Urokinase Plasminogen Activator in Prostate Carcinoma Cells
It is reported that prostate carcinoma cells LNCaP and PC3 autoactivate latent full-length PDGF D into its active form under serum-independent conditions and that this autoactivation is inhibited by PAI-1, a urokinase plasminogen activator (uPA)/tissue plasmineogen activators (tPA) inhibitor.
Platelet-derived growth factor-C (PDGF-C) activation by serine proteases: implications for breast cancer progression.
- N. Hurst, Abdo J. Najy, C. Ustach, L. Movilla, H. Kim
- BiologyBiochemical Journal
- 1 February 2012
TPA (tissue plasminogen activator) and matriptase as major proteases for processing of PDGF-C in MCF7 cells are identified and by site-directed mutagenesis, the cleavage site for these proteases in PD GF-C is identified.
Interactions between tobacco mosaic virus and the tobacco N gene.
- F. L. Erickson, S. Dinesh-Kumar, B. Baker
- BiologyPhilosophical transactions of the Royal Society…
- 29 March 1999
Both components of this gene-for-gene interaction between tobacco mosaic virus and tobacco harbouring the N gene are now available for studies that address the molecular mechanisms involved in N-mediated TMV resistance.
Tag1 is an autonomous transposable element that shows somatic excision in both Arabidopsis and tobacco.
- M. Frank, D. Liu, Y. Tsay, C. Ustach, N. Crawford
- Environmental ScienceThe Plant Cell
- 1 October 1997
Blue-staining sectors were found in cotyledons, leaves, and roots, showing that Tag1 undergoes somatic excision during vegetative development in its native host.
Molecular and Cellular Pathobiology A Novel Signaling Axis of Matriptase / PDGF-D / b-PDGFR in Human Prostate Cancer
A novel signaling axis of matriptase/PDGF-D/b-PDGFR in PCa is unveiled, providing new insights into functional interplay between serine protease and growth factor signaling networks.
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