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Willingness to pay for three hypothetical malaria vaccines in Nigeria.
TLDR
It appears that although malaria is a serious disease, the Nigerian people in this sample preferred and were willing to pay more for a vaccine that was well tolerated, even if its effectiveness and duration of protection against malaria were lower than those of a product that caused severe adverse effects.
Isolation and characterization of 3-carbomethoxypyridine from the leaves of Pyrenacantha staudtii Hutch and Dalz (Icacinaceae).
TLDR
The chemical isolation and characterization of 3-carbomethoxypyridine from one of the active fractions of the methanolic extract of Pyrenacantha staudtii leaves is reported for the first time.
Ebola Virus Epidemic in West Africa: Global Health Economic Challenges, Lessons Learned, and Policy Recommendations.
TLDR
Curbing the impact of future Ebola epidemics, or comparable diseases, requires increased long-term investments in health system strengthening, better collaboration between different international organizations, more funding for research and development efforts aimed at developing vaccines and treatments, and tools to detect, treat, and prevent future epidemics.
Adsorptive property of kaolin in some drug formulations
Purpose: Kaolin is a known ad sorbent, has lubricant property in po wders and is therefore proposed as a lubricant in tablet formulations. This study was carried out to evaluate whether kaolin can ad
Phytochemical investigation and anti-inflammatory property of ethanol-water extract of the roots of Anthocleista djalonensis A. Chev. (Gentianiaceae)
Anthocleista djalonensis A.Chev. (Gentianiaceae) a plant of West African origin is used for the treatment of inflammatory disorders traditionally. Phytochemical screening of the plant root material
Novel diphenysulphapyrimidine acetates derived from chalcones
Cyclocondensation of sulphaguanidine acetate with chalcones in dimethylsulphoxide at 110° gave 4,6-diphenylsulphapyrimidine acetates.
Synthesis and anticonvulsant activity of N,N‐phthaloyl derivatives of central nervous system inhibitory amino acids
TLDR
G glycine‐derived amides showed a higher activity than the β‐alanine and GABA derivatives in the maximal electroshock seizure (MES) test in mice upon intraperitoneal administration and might represent promising antiepileptic drugs.
Studies on quinazolines. 11. Intramolecular imidate-amide rearrangement of 2-substituted 4-(omega-chloroalkoxy)quinazoline derivatives. 1,3 -O --> N shift of chloroalkyl groups via cyclic
TLDR
Investigation of the O-alkylated products, 4-omega-chloroalkoxyquinazolines, revealed that the migration of omega- chloroethyl and omega-chloropropyl groups from oxygen to nitrogen should be intramolecular via five- and six-membered cyclic 1,3-azaoxonium intermediates, respectively.
Synthesis and Anticonvulsant Activity of Acetylenic Quinazolinone Derivatives
TLDR
Most compounds displayed seizure‐antagonizing activity in the maximal electroshock test (MES test) in most cases associated with little or no acute neurotoxicity determined in the rotorod test.
Anti-inflammatory and gastroprotective properties of some chalcones.
TLDR
The synthesis of 1,3-diaryl propen-1-ones by the Claisen-Schmidt condensation between acetophenones and benzaldehydes in potassium hydroxide/methanol medium at room temperature was found to have anti-inflammatory and anti-ulcer activities.
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