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Pharmacodynamic effects and pharmacokinetic profile of a long-term continuous rate infusion of racemic ketamine in healthy conscious horses.
TLDR
It was concluded that a KET CRI of 1.5 mg/kg/h can safely be administered to healthy conscious horses for at least 6 h, although a slight modification of the initial infusion rate regimen may be indicated. Expand
EIPH: postrace endoscopic evaluation of Standardbreds and Thoroughbreds.
TLDR
There was no apparent effect of breed (or possibly racing gait) on EIPH, and no differences in the incidence or severity of EipH were observed between horses with or without prerace frusemide administration. Expand
Pharmacokinetics of dexamethasone following intra-articular, intravenous, intramuscular, and oral administration in horses and its effects on endogenous hydrocortisone.
TLDR
The pharmacokinetic estimates for intra-articular (IA) administration of dexamethasone sodium phosphate into three equine joints, femoropatellar (IAS), radiocarpal (IAC), and metacarpophalangeal (IAF), and the intramuscular (IM), oral (PO) and intravenous (IV) administrations were compared. Expand
Pharmacokinetics of fentanyl administered transdermally and intravenously in sheep.
TLDR
Investigation of the pharmacokinetics of fentanyl administered transdermally and IV in sheep resulted in a short half-life and application of a TFP resulted in stable blood fentanyl concentrations in sheep. Expand
Pharmacokinetics of dexamethasone with pharmacokinetic/pharmacodynamic model of the effect of dexamethasone on endogenous hydrocortisone and cortisone in the horse.
A compartmental model was used to describe the pharmacokinetics of dexamethasone (DXM) and changes in the plasma concentration of endogenous cortisone (COR) and hydrocortisone (HYD) followingExpand
LC−MS/MS Method for Confirmation of Recombinant Human Erythropoietin and Darbepoetin α in Equine Plasma
Recombinant human erythropoietin (rhEPO) and darbepoetin α (DPO) are protein-based drugs for the treatment of anemia by stimulating red blood cell production. Consequently, they are abused in humanExpand
Pharmacokinetics of intra-articular, intravenous, and intramuscular administration of triamcinolone acetonide and its effect on endogenous plasma hydrocortisone and cortisone concentrations in horses.
TLDR
Pharmacokinetics of TA and related changes in hydrocortisone were described following i.v., i.a.a., and i.m. administration, and plasma concentrations of hydroc Cortisone did not recover to baseline concentrations by 360 hours. Expand
Pharmacokinetic profile and pharmacodynamic effects of romifidine hydrochloride in the horse.
TLDR
The drug produces long-lasting sedation in horses that corresponds with the long terminal elimination half-life of the drug, and detailed description of its PK profile is described. Expand
Pharmacokinetics of boldenone and stanozolol and the results of quantification of anabolic and androgenic steroids in race horses and nonrace horses.
TLDR
Anabolic steroids and androgenic steroids in plasma were quantified using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and testosterone was not quantified in nonracing geldings and female horses, but was in racing females and gelding. Expand
Detection, quantification and confirmation of anabolic steroids in equine plasma by liquid chromatography and tandem mass spectrometry.
TLDR
The method was successfully applied to analyses of equine plasma samples for pharmacokinetics study and is sensitive and useful for detection, quantification and confirmation of these anabolic steroids inequine plasma. Expand
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