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Epithelial Inflammation Is Associated with CCL28 Production and the Recruitment of Regulatory T Cells Expressing CCR101
Mucosal tissues require constant immune surveillance to clear harmful pathogens while maintaining tolerance to self Ags. Regulatory T cells (Tregs) play a central role in this process and expression… Expand
The rate of oesophageal adenocarcinoma is increasing in the western world and has a poor prognosis mainly because individuals present at a late stage. Attempts to intervene at an early stage of… Expand
Modulation of iron transport proteins in human colorectal carcinogenesis
Background and aims: Total body iron and high dietary iron intake are risk factors for colorectal cancer. To date there is no comprehensive characterisation of iron transport proteins in progression… Expand
Epithelial-mesenchymal transition mediated tumourigenesis in the gastrointestinal tract.
Epithelial-mesenchymal transition (EMT) is a highly conserved process that has been well characterised in embryogenesis. Studies have shown that the aberrant activation of EMT in adult epithelia can… Expand
Overexpression of Cellular Iron Import Proteins Is Associated with Malignant Progression of Esophageal Adenocarcinoma
- J. Boult, K. Roberts, +7 authors C. Tselepis
- Medicine, Biology
- Clinical Cancer Research
- 15 January 2008
Purpose: There is growing evidence that iron is important in esophageal adenocarcinoma, a cancer whose incidence is rising faster than any other in the Western world. However, how iron mediates… Expand
Increased hepcidin expression in colorectal carcinogenesis.
AIM To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anaemia and whether it might have a role in colorectal carcinogenesis. METHODS Mass… Expand
Tumour necrosis factor-alpha in Barrett's oesophagus: a potential novel mechanism of action.
Barrett's metaplasia (BM) is an early lesion in the progression from oesophageal inflammation through dysplasia to the development of Barrett's adenocarcinoma (BA). Previous work indicates that BM… Expand
Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: need for standardization
This study indicates that hepcidin levels reported by various methods vary considerably but analytical variance is generally low and similar for all methods. See related perspective article on page… Expand
Desmosomal adhesion inhibits invasive behavior.
- C. Tselepis, M. Chidgey, A. North, D. Garrod
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 7 July 1998
Recent studies of human disease and transgenic animal experiments have clearly demonstrated the importance of desmosomes in normal tissue architecture. Furthermore, desmosomal components are… Expand
Luminal iron levels govern intestinal tumorigenesis after Apc loss in vivo.
It is clear from epidemiological studies that excess iron is associated with increased risk of colorectal cancer; however, questions regarding the mechanism of how iron increases cancer risk, the… Expand