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Chronic Hypoxia–Induced Upregulation of Store-Operated and Receptor-Operated Ca2 Channels in Pulmonary Arterial Smooth Muscle Cells: A Novel Mechanism of Hypoxic Pulmonary Hypertension
Both store- and receptor-operated channels of PASMCs are upregulated by chronic hypoxia and contribute to the enhanced vascular tone in hypoxic pulmonary hypertension. Expand
Kinetic and Pharmacological Properties of Cloned Human Equilibrative Nucleoside Transporters, ENT1 and ENT2, Stably Expressed in Nucleoside Transporter-deficient PK15 Cells
It is suggested that hENT2 might be important in transporting adenosine and its metabolites (inosine and hypoxanthine) in tissues such as skeletal muscle where ENT2 is predominantly expressed. Expand
cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein.
  • C. Yun, S. Oh, +5 authors M. Donowitz
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 April 1997
Two regulatory proteins are identified, E3KARP and NHERF, that interact with NHE3 to enable cAMP to inhibit NHE2 and these proteins are structurally related, sharing approximately 50% identity in amino acid sequences. Expand
NHE2 and NHE3 are human and rabbit intestinal brush-border proteins.
Rabbit NHE2 and NHE3 are two epithelial isoform Na+/H+ exchangers (NHE), the messages for which are found predominantly and entirely, respectively, in renal, intestinal, and gastric mucosa. TheExpand
NHERF family and NHE3 regulation
Specificity for only one member of the NHERF family in one example of NHE3 regulation, inhibition by elevation in cGMP, is used to describe how N HERF family proteins are involved in N HE3 complex formation and its regulation. Expand
Kinetics and regulation of three cloned mammalian Na+/H+ exchangers stably expressed in a fibroblast cell line.
The differences in kinetics and second messenger regulation suggest that the NHE isoforms may serve different cellular functions, and the up- and down-regulation of NHE3 by kinases indicates that this isoform may be involved in a specialized function such as Na+ absorption. Expand
Mammalian Na+/H+ exchanger gene family: structure and function studies.
The present review deals with the recent developments in the molecular identification of the Na+/H+ exchanger gene family, the functional characteristics, and the short-term regulation of Na-H+ exchange at molecular and cellular levels. Expand
Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3.
The data suggest that cellular localization of hent3 is cell type dependent and the native transporter is substantially expressed in mitochondria and/or cell surface, and hENT3-mediated mitochondrial transport may play an important role in mediating clinically observed mitochondrial toxicity of nucleoside drugs. Expand
Cloning and sequencing of a rabbit cDNA encoding an intestinal and kidney-specific Na+/H+ exchanger isoform (NHE-3).
The cloning of a composite cDNA which encodes a third mammalian isoform (NHE-3), which is expressed specifically in intestine and kidney is reported, which is likely a glycoprotein as it has one potential N-linked glycosylation site, which was conserved in all NHEs identified. Expand
Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3.
Northern analysis of multiple human tissues detected NHE3 message, in descending order, as follows: kidney >> small intestine >> testes > ovary > colon = prostate > thymus > peripheral leukocyte = brain > spleen > placenta. Expand