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Early Survival and Safety of ALPPS: First Report of the International ALPPS Registry
Objectives:To assess safety and outcomes of the novel 2-stage hepatectomy, Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS), using an international registry.… Expand
ALPPS Offers a Better Chance of Complete Resection in Patients with Primarily Unresectable Liver Tumors Compared with Conventional-Staged Hepatectomies: Results of a Multicenter Analysis
BackgroundPortal vein occlusion to increase the size of the future liver remnant (FLR) is well established, using portal vein ligation (PVL) or embolization (PVE) followed by resection 4–8 weeks… Expand
ALPPS: From Human to Mice Highlighting Accelerated and Novel Mechanisms of Liver Regeneration
Objectives:To develop a reproducible animal model mimicking a novel 2-staged hepatectomy (ALPPS: Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy) and explore the… Expand
Prediction of Mortality After ALPPS Stage-1: An Analysis of 320 Patients From the International ALPPS Registry.
OBJECTIVES The aim of this study was to identify predictors of 90-day mortality after Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS), available after stage-1,… Expand
Liver failure after extended hepatectomy in mice is mediated by a p21-dependent barrier to liver regeneration.
BACKGROUND & AIMS Extended liver resection leads to hepatic failure because of a small remnant liver volume. Excessive parenchymal damage has been proposed as the principal cause of this failure, but… Expand
GPR120 on Kupffer cells mediates hepatoprotective effects of ω3-fatty acids.
BACKGROUND & AIMS Many of the beneficial effects of ω3-fatty acids (ω3FAs) are being attributed to their anti-inflammatory properties. In animal models, ω3FAs also protect from hepatic ischemia… Expand
Systematic Review and Meta-Analysis of Feasibility, Safety, and Efficacy of a Novel Procedure: Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy
- E. Schadde, A. Schnitzbauer, C. Tschuor, D. Raptis, W. Bechstein, P. Clavien
- Annals of Surgical Oncology
- 1 September 2015
BackgroundAssociating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a novel strategy to resect liver tumors despite the small size of the liver remnant. It is an… Expand
Constitutive androstane receptor (Car)-driven regeneration protects liver from failure following tissue loss.
BACKGROUND & AIMS Liver can recover following resection. If tissue loss is too excessive, however, liver failure will develop as is known from the small-for-size-syndrome (SFSS). The molecular… Expand
In vitro norepinephrine significantly activates isolated platelets from healthy volunteers and critically ill patients following severe traumatic brain injury
IntroductionNorepinephrine, regularly used to increase systemic arterial blood pressure and thus improve cerebral perfusion following severe traumatic brain injury (TBI), may activate platelets.… Expand
Adrenergic crisis induced by a pheochromocytoma leads to life‐threatening catecholamine‐induced hemodynamic disturbances. Successful treatment of a pheochromocytoma crisis demands prompt diagnosis,… Expand