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Tricellulin deficiency affects tight junction architecture and cochlear hair cells.
The two compositionally distinct extracellular cochlear fluids, endolymph and perilymph, are separated by tight junctions that outline the scala media and reticular lamina. Mutations in TRIC (alsoExpand
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Adrenomedullin Induces Cardiac Lymphangiogenesis After Myocardial Infarction and Regulates Cardiac Edema Via Connexin 43
Rationale: Cardiac lymphangiogenesis contributes to the reparative process post-myocardial infarction, but the factors and mechanisms regulating it are not well understood. Objective: To determine ifExpand
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Partner associations across sympatric broad‐headed bug species and their environmentally acquired bacterial symbionts
Many organisms have intimate associations with beneficial microbes acquired from the environment. These host–symbiont associations can be specific and stable, but they are prone to lower partnerExpand
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Molecular genetics of MARVELD2 and clinical phenotype in Pakistani and Slovak families segregating DFNB49 hearing loss
Pathogenic mutations of MARVELD2, encoding tricellulin, a tricelluar tight junction protein, cause autosomal recessive non-syndromic hearing loss (DFNB49) in families of Pakistan and Czech RomaExpand
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Endothelial Restoration of Receptor Activity–Modifying Protein 2 Is Sufficient to Rescue Lethality, but Survivors Develop Dilated Cardiomyopathy
RAMPs (receptor activity–modifying proteins) serve as oligomeric modulators for numerous G-protein–coupled receptors, yet elucidating the physiological relevance of these interactions remainsExpand
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Lymphatic Function and Dysfunction in the Context of Sex Differences.
  • C. Trincot, K. Caron
  • Medicine, Biology
  • ACS pharmacology & translational science
  • 9 September 2019
Endothelial cells are the building blocks of the blood vascular system and exhibit well-characterized sexually dimorphic phenotypes with regard to chromosomal and hormonal sex, imparting innateExpand
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A Distinct Mechanism of Vascular Lumen Formation in Xenopus Requires EGFL7
During vertebrate blood vessel development, lumen formation is the critical process by which cords of endothelial cells transition into functional tubular vessels. Here, we use Xenopus embryos toExpand
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Genetic loss of proadrenomedullin N-terminal 20 peptide (PAMP) in mice is compatible with survival
HIGHLIGHTSFirst genetic allele in mice resulting in deletion of PAMP peptide, a proteolytic by‐product of the adrenomedullin gene.PAMP deletion is compatible with embryonicExpand
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