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Capturing and profiling adult hair follicle stem cells
The hair follicle bulge possesses putative epithelial stem cells. Characterization of these cells has been hampered by the inability to target bulge cells genetically. Here, we use a Keratin1-15Expand
Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34.
It is widely believed that epithelial stem cells reside in the hair follicle bulge region. We investigated the hematopoietic stem and progenitor cell marker, CD34, as a potential marker of hairExpand
Effects of fixation on RNA extraction and amplification from laser capture microdissected tissue
One of the key end points for understanding the molecular basis of carcinogenesis is the quantitation of gene expression in specific cell populations. Microdissection techniques allow extraction ofExpand
Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology
Hyaluronan signaling properties are unique among other biologically active molecules, that they are apparently not influenced by postsynthetic molecular modification, but by hyaluronan fragment size.Expand
CD34 expression by hair follicle stem cells is required for skin tumor development in mice.
The cell surface marker CD34 marks mouse hair follicle bulge cells, which have attributes of stem cells, including quiescence and multipotency. Using a CD34 knockout (KO) mouse, we tested theExpand
Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice.
In Drosophila and Caenorhabditis elegans, kinase suppressor of ras (KSR) positively modulates Ras/Raf-mitogen-activated protein kinase (MAPK) signaling. The precise signaling mechanism of mammalianExpand
In vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis.
Cancer progresses through distinct stages, and mouse models recapitulating traits of this progression are frequently used to explore genetic, morphological, and pharmacological aspects of tumorExpand
PTEN positively regulates UVB-induced DNA damage repair.
Nonmelanoma skin cancer is the most common cancer in the United States, where DNA-damaging ultraviolet B (UVB) radiation from the sun remains the major environmental risk factor. However, theExpand
Inhibition of ornithine decarboxylase (ODC) decreases tumor vascularization and reverses spontaneous tumors in ODC/Ras transgenic mice.
We have shown that ornithine decarboxylase (ODC) overexpression in the skin of TG.AC v-Ha-ras transgenic mice induces the formation of spontaneous skin carcinomas. Treatment of ODC/Ras doubleExpand
Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo.
Cyclin D1 is part of a cell cycle control node consistently deregulated in most human cancers. However, studies with cyclin D1-null mice indicate that it is dispensable for normal mouse developmentExpand
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